Main description:

In this book, the author has given a comprehensive description of 101 medical autopsy cases (48 adult and 53 pediatric) with their complete clinical and pathological details. Each case is unique and has been discussed in a simple, practical, straightforward, but comprehensive manner.

Comprehensive compilation of 101 medical autopsy cases (48 adult and 53 pediatric - children, infants, neonates, stillbirths and terminated fetuses) in a case based manner.
First book in the world literature to have compiled medical autopsy cases with complete clinical and pathological details, and agallery of gross and microscopic pictures with review of literature.
The cases have been grouped in the following order: hematologic disorders, malignancies, infections, hepatobiliary and pancreatic disorders, cardiovascular system, systemic vasculitides, primary renal mucormycosis, histiocytosis, primary immunodeficiency, infantile nephrotic syndromes, congenital heart disease, storage disorder and pediatric renal cystic disease (developmental/genetic/syndromes).
Introduction to medical autopsy, systemic vasculitides, tubercular meningitis and pediatric renal cystic diseases are added for better understanding.
Each autopsy case is a complete journey of the patient/deceased and has been concisely discussed under the following headings: title, highlights of the case, clinical details, investigations, clinical diagnosis, complete histopathological or autopsy findings with a gallery of gross and microscopic photographs (3,000 plus), final autopsy diagnosis, review of literature, commentary index case, take home message and suggested reading or references.
This book will be a great teaching material for the pathologists, medical physicians, pediatricians, neonatologists, obstetricians, radiologists along with undergraduates/postgraduates students.

Contents:

Introduction

Medical Autopsy: The Strongest Teaching Tool in Medicine

Section 1: Hematological Disorders-Adult Cases

Case 1: Mantle Cell Lymphoma, Presenting with Florid Cutaneous Lesions, with Common Variant Morphology in the Nodal/Extranodal Sites and Blastoid Morphology in the Peripheral Blood:PM 25983

Case 2: Primary Myelofibrosis, Cellular Phase with Formation of Sclerosing Extramedullary Hematopoietic Tumors: PM 27873

Case 3: Primary Myelofibrosis, Cellular Phase with Extensive Extramedullary Hematopoiesis and Transformation into Acute Leukemia: PM 23618

Case 4: Hepatosplenic T-cell Lymphoma: PM 23096

Case 5: Acute Promyelocytic Leukemia with Early Death due to Disseminated Intravascular Coagulation and Right Temporal Lobe Hemorrhage: PM 26880

Case 6: Acute Promyelocytic Leukemia with Differentiation Syndrome: PM 17959

Case 7: Chronic Lymphatic Leukemia, Post-Bone Marrow Transplantation with Recurrence, Massive Lymphadenopathy and Hemophagocytosis: PM 21710

Case 8: Symptomatic Plasma Cell Myeloma with Primary Systemic Amyloidosis Showing a Predominant Involvement of the Heart and Gastrointestinal Tract: PM 19667

Section 2: Malignancy-Adult Cases

Case 9: Microscopic/Occult Testicular Seminoma with Germ Cell Neoplasia in situ and Widespread Nonseminomatous Metastasis in a Young Male: PM 14170

Case 10:Malignant Teratoma, Primary Pulmonary, Containing Yolk Sac tumor, Associated with Hematologic Neoplasia: PM 13633

Case 11:Young Male with Metastasis: Do not Waste Time-Look for the Primary in the Testes: PM 19388

Case 12: Occult, Peripheral, Mucin-secreting Adenocarcinoma of Lung with Florid Meningeal Carcinomatosis along with Thrombotic Microangiopathy and Disseminated Intravascular Coagulation, Leading to Bilateral Renal Infarction: PM 26226

Case 13: Young Male with Occult, Diffuse Type, Mucin-secreting Adenocarcinoma of the Stomach with Extensive Lymphangitic Carcinomatosis, Presenting with Deep Vein Thrombosis and Pulmonary Embolism: PM 21829

Section 3: Infections-Adult Cases

Case 14: Amebic Ileocolitis, Perforation and Liver Abscess: PM 18836

Case 15: Cerebral Toxoplasmosis in a Human Immunodeficiency Virus Positive Patient: PM 19210

Case 16: Pulmonary Hyalinizing Granuloma with Recent Onset Cryptococcal Meningoencephalitis in an Immunocompetent Male: PM 21122

Case 17: Leptospirosis with Multiorgan Involvement: PM 22793

Case 18: Silicotuberculosis: PM 26075

Case 19: Rabies Meningoencephalitis, Post-Pet Dog Bite: PM 27786

Section 4: Hepatobiliary and Pancreatic Disorders-Adult Cases

Case 20: Extrahepatic Portal Venous Obstruction due to Cavernomatous Transformation of Portal Vein and Portal Cavernoma Cholangiopathy: PM 22260

Case 21: Chronic Budd-Chiari Syndrome with Mesoatrial Shunt, Venocentric Cirrhosis, Hepatocellular Carcinoma Infiltrating into the Hepatic Duct Causing Obstruction and Hemobilia: PM 27800

Case 22: Acute on Chronic Pancreatitis Leading to Portal Vein Pyemia, with Multiple Liver Abscesses and Life-threatening Sepsis Shock: PM 25975

Case 23: Lipomatous Pseudohypertrophy of the Pancreas with Polyglandular Autoimmune Syndrome Type II and Inflammatory Myopathy: PM 22590

Case 24: Young Male with Early Onset Micronodular Cirrhosis due to Synergistic Hepatotoxic Effect of Alcohol and Hepatitis C Virus Infection along with Cryoglobulinemic Vasculitis: PM 27791

Case 25: Diffuse Hepatocellular Carcinoma Arising in a Setting of Mixed Nodular Cirrhosis, Hepatitis C Virus and Alcohol Related: PM 26695

Case 26:Acute Liver Failure and Encephalopathy in a Case of Dengue Shock Syndrome: PM 25035

Case 27: Postpartum, Hyperacute, Fulminant Hepatic Failure due to Hepatitis E Virus: PM 26595

Case 28: Sporadic, Hepatitis E-related Massive Hepatic Necrosis in a Young Female: PM 26254

Case 29: A Classical Case of Wilson's Disease with Hepatic and Neuropsychiatric Manifestations: PM 26195

Section 5: Cardiovascular System-Adult Cases

Case 30: Silent Healed Myocardial Infarction and its Complications-Infarct Expansion, Mural Thrombosis, Aneurysm Formation, Extensive Arterial Embolization, Deep Vein Thrombosis and Subsequent Fatal Venous Thromboembolism: PM 21817

Case 31: Coexistence of Acute-on-Chronic Rheumatic Heart Disease and Acute Poststreptococcal Glomerulonephritis: PM 21119

Case 32: A Classical Case of Marfan Syndrome with Aortic Root Dilatation, Aneurysm of the Ascending Aorta and Acute Aortic Dissection: PM 22554

Case 33: Adult Tetralogy of Fallot with Tricuspid Valve Infective Endocarditis and Thromboembolic Botryomycotic Cerebral Abscess: PM 26941

Case 34: Cocaine-induced Vasculopathy Leading to Cardiomyopathy, Renal Infarcts, Gangrene of Digits with Autoamputation: PM 23445

Case 35: Aftermath of Hypertension in a Middle-aged Male-Intraparenchymal Brain Hemorrhage, Pontine and Thalamic: PM 26485

Section 6: Systemic Vasculitides-Adult and Pediatric Cases

Systemic Vasculitides-Introduction

Small Vessel Vasculitides

Case 36: Renal Limited Microscopic Polyangiitis: PM 13127

Case 37: Microscopic Polyangiitis, ANCA Negative, with Florid Glomerulitis and Granulomatous Glomerulonephritis: PM 15649

Case 38: Microscopic Polyangiitis in a Child: PM 16450

Case 39: Microscopic Polyangiitis, ANCA Negative, Clinically Mimicking Granulomatosis with Polyangiitis (Wegener's Granulomatosis) and Presenting with a Breast Mass: PM 18473

Case 40: Microscopic Polyangiitis-Chronic Phase: PM 18987

Case 41: Microscopic Polyangiitis with Acute Vasculitis of Small, Medium and Large-sized Arteries: PM 20415

Case 42: p-ANCA Positive Classic Polyarteritis Nodosa: PM 24277

Case 43: Takayasu's Aortoarteritis, Pulmonary Hypertension, and Pulmonary Capillary Hemangiomatosis: PM 14993

Case 44: Takayasu Aortoarteritis, Presenting with Pulmonary Arterial Hypertension Secondary to Extensive Involvement of Right Pulmonary Artery: PM 25988

Case 45: Granulomatosis with Polyangiitis (Wegener's Granulomatosis) with Left Foot Gangrene and Right Hemiplegia: PM 14106

Case 46: Granulomatosis with Polyangiitis-Wegener's Granulomatosis, Presenting as an Anterior Mediastinal Mass: PM 18613

Case 47: Granulomatosis with Polyangiitis, i.e Wegener's with Multiple Pulmonary Nodules and Total Splenic Necrosis: PM 21594

Case 48: c-ANCA Positive, Nonreactive, Disseminated Tuberculosis with Pulmonary and Mesenteric Vasculitis: PM 14513

Section 7: Primary Renal Mucormycosis-Adult and Pediatric Cases

Case 49: Isolated Bilateral Renal Mucormycosis with Contiguous Spread to the Adrenals, Mesentery, Pancreas and Colon in an Apparently Immunocompetent Adult: PM 27250

Case 50: Primary Bilateral Renal Mucormycosis in an Apparently Immunocompetent Child: PM 22863

Section 8: Histiocytosis-Pediatric and Adult Cases

Case 51: Primary/Familial Hemophagocytic Lymphohistiocytosis with Extensive Involvement of the Brain: PM 20788

Case 52: Langerhans Cell Histiocytosis Presenting as an Anterior Mediastinal Mass: PM 21476

Case 53: Macrophage Activation Syndrome-A Fatal Complication of Systemic Onset Juvenile Idiopathic Arthritis: PM 26202

Case 54: Epstein-Barr Virus-associated Secondary Hemophagocytic Lymphohistiocytosis-

A Rare Complication: PM 21703

Section 9: Primary Immunodeficiency-Pediatric Cases

Case 55: Disseminated Bacillus Calmette-Guerin Infection in a Case of Severe Combined

Immunodeficiency: PM 22931

Case 56: Chronic Granulomatous Disease of Childhood: PM 24170

Case 57: Disseminated Nonreactive Tuberculosis, PCR-Proven Dual Positivity for Mycobacterium Tuberculosis and Abscessus ? Mendelian Susceptibility to Mycobacterial Disease: PM 25174

Section 10: Infantile Nephrotic Syndrome

Case 58: Congenital Nephrotic Syndrome of the Finnish Type: PM 23777

Case 59: Infantile Nephrotic Syndrome-Diffuse Mesangial Sclerosis in a 10-Month-Old Male Child: PM 26462

Section 11: Infections-Pediatric Cases

Case 60: Disseminated Congenital Cytomegalovirus Infection with Islet Cell Hyperplasia as the Cause of Persistent Hypoglycemia in a Neonate: PM 23822

Case 61: Congenital Tuberculosis: An Underdiagnosed Entity: PM 24753

Case 62: Disseminated Cryptococcomas Mimicking Disseminated Malignancy, with Hepatic Dysfunction as the Initial Manifestation, in an Immunocompetent Child: PM 25744

Introduction to Tubercular Meningitis

Case 63: Catastrophic Posterior Circulation Tubercular Arteritis with Infarcts and Cortical

Venous Thrombosis-A Rare Co-existence: PM 26344

Case 64: Child with Disseminated Miliary Tuberculosis, Tubercular Meningitis with

Extensive Arteritis, Infarction and Ischemic Hepatitis: PM 25901

Case 65: Disseminated Cryptococcal Infection in an HIV-positive Child: PM 23563

Section 12: Cardiovascular System-Pediatric Case

Case 66: Transposition of Great Arteries: PM 24027

Section 13: Hematological Disorders-Pediatric Cases

Case 67: Child with Acute Lymphoblastic Leukemia on Induction Therapy with Febrile

Neutropenia and Disseminated Aspergillus Infection: PM 25927

Case 68: Myeloid Sarcoma of Lacrimal Sac as the First Manifestation of AML-M1 with Acute Diffuse Colorectal Neutropenic Colitis in a Child: PM 23395 576

Section 14: Storage Disorder

Case 69: Niemann-Pick Type B Presenting with Massive Splenohepatomegaly and Hypertensive Crisis in a 12-year-old Child: PM 27096

Section 15: Pediatric Renal Cystic Disease (Developmental/Genetic/Syndromes)

Pediatric Cystic Disease (Developmental/Genetic) of Kidney-Introduction

Section 15A: Renal Dysplasia

Case 70: Recurrent Bilateral Multicystic Dysplastic Kidneys, Consistent with Hereditary

Renal Adysplasia: PM 20505

Case 71: Symmetrically Enlarged, Solid Dysplastic Kidneys with Intrauterine Growth

Retardation: PM 24340

Case 72: Multicystic Dysplastic Kidneys with Dilated Ureters and Hypertrophied Urinary

Bladder Leading to Obstructed Labor and Uterine Rupture: PM 26207

Case 73-74: Renal Hypodysplasia: PM 19521, PM 25711 619

Nandita Bharadwaj Kakkar

Case 75: Bilateral Renal Agenesis: PM 24019

Case 76-80: Unilateral Renal Malformation: PM 22428, PM 22393, PM 26428, PM 26291, PM 26824

Case 81: Segmental Renal Dysplasia with Duplex Kidney and Ureterocele: PM 19965

Section 15B: Posterior Urethral Valve

Case 82-83: Posterior Urethral Valve Leading to Congenital Hydroureteronephrosis and

Hypertrophied Urinary Bladder: PM 18485, PM 26118

Section 15C: Renal Hypoplasia

Case 84: Neonate with Bilateral Simple Renal Hypoplasia, Lung Hypoplasia and Hydrocephalous: PM 27245

Case 85: Bilateral Simple Renal Hypoplasia, Cystic Periventricular Leukomalacia with Hydrocephalus ex vacuo in Surviving Twin, after death of Monochorionic Co-twin: PM 25677

Case 86: Segmental Hypoplasia (Ask-Upmark Kidney): S-14525/2008

Section 15D: Genetic Disorders

Case 87: A Classical Case of Autosomal Recessive Polycystic Kidney Disease: PM 22879

Case 88: Autosomal Dominant Polycystic Kidney Disease with Cyst Infection: PM 22828

Section 15E: Glomerulocystic Kidney Disease

Case 89: Co-existing Glomerulocystic Kidney Disease and Renal Tubular Dysgenesis with Late Onset Oligohydramnios and Renal Failure at D2 of Life: PM 28154

Case 90: Glomerulocystic Kidney Associated with Posterior Urethral Valve- A Rare Association: PM 28255

Section 15F: Syndromes

Case 91-92: Meckel-Gruber Syndrome: PM 20070, PM 26190

Case 93-94: Prune Belly Syndrome Leading to a Markedly Distended Urinary Bladder and

Hydroureteronephrosis: PM 23424, PM 25509

Case 95: Sirenomelia with Bilateral Renal Agenesis and Multiple Other Malformations: PM 27025

Section 16: Liver Disorders-Pediatric Cases

Case 96: Coexistence of Duarte 2 Variant of Galactosemia with Niemann-Pick Disease Type B, in an Infant: PM 23108

Case 97: A Classical Case of Galactosemia: PM 23869

Case 98: Galactosemia, Double Heterozygous for N314D and Q188R Mutations, with

Micronodular Cirrhosis and Absence of Steatosis: PM 25342

Case 99: A Case of Galactosemia, Double Heterozygous for Q188R and E308K Mutations with Early Neonatal Acute Liver Failure: PM 25552

Case 100: Neonate with Hemolytic Disease of Newborn (Due to Rh Isoimmunization-for both Rh-D Antigen and Rh-C Antigen), Conjugated Hyperbilirubinemia, and Associated Nonsyndromic Paucity of Intrahepatic Bile Ducts: PM 27937

Case 101: Indian Childhood Cirrhosis: PM 24527

Abbreviations

Index