Main description:

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Contents:

Chapter 1 - What is Pharmacology?
Chapter 2 - How Different Tissues Process Drug Response
Chapter 3 - Drug Receptor Theory
Chapter 4 - Pharmacological Assay Formats: Binding
Chapter 5 - Agonists: The Measurement of Affinity and Efficacy in Functional Assays
Chapter 6 - Orthosteric Drug Antagonism
Chapter 7 - Allosteric Drug Interactions
Chapter 8 - Drug Discovery
Chapter 9 - Drug Development: Pharmacokinetics and Safety Pharmacology
Chapter 10 - Target-and System-based Strategies for Drug Discovery
Chapter 11 - Lead Optimization: Data-Driven Analysis
Chapter 12 - Statistics and Experimental Design
Chapter 13 - Selected Pharmacological Methods
Chapter 14 - Exercises in Pharmacodynamics and Pharmacokinetics
Glossary of Pharmacological Terms
Appendices
Statistical Tables
Mathematical Fitting Functions