Main description:

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more.

With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research.

Contents:

1. What Is Pharmacology? 2. How Different Tissues Process Drug Response 3. Drug-Receptor Theory 4. Pharmacological Assay Formats: Binding 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays 6. Orthosteric Drug Antagonism 7. Allosteric Modulation 8. The Optimal Design of Pharmacological Experiments 9. Pharmacokinetics 10. Safety Pharmacology 11. The Drug Discovery Process 12. Statistics and Experimental Design 13. Selected Pharmacological Methods 14. Exercises in Pharmacodynamics and Pharmacokinetics