Main description:

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer's Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.

Contents:

A Brief Introduction to the History of the ss-Amyloid Protein (Ass) of Alzheimer's Disease.- The Asscentric Pathway of Alzheimer's Disease.- The Function of the Amyloid Precursor Protein Family.- The involvement of Ass in the neuroinflammatory response.- Amyloid ss-Peptide(1-42), Oxidative Stress, and Alzheimer's Disease.- Amyloid Toxicity, Synaptic Dysfunction and the Biochemistry of Neurodegeneration in Alzheimer's Disease.- Ass Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression.- Copper Coordination by ss-Amyloid and the Neuropathology of Alzheimer's Disease.- Cholesterol and Alzheimer's Disease.- Amyloid ss peptide and central cholinergic neurons: involvement in normal brain function and Alzheimer's disease pathology.- Physiological and Neurotoxic Properties of Ass Peptides.- Impact of ss-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models.- Glial Cells and Ass Peptides in Alzheimer's Disease Pathogenesis.- The Role of Presenilins in Abeta-Induced Cell Death in Alzheimer's Disease.- Immunotherapeutic approaches to Alzheimer's disease.- Mouse Models of Alzheimer's Disease.