Main description:

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.
The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

Contents:

Chapter 1 Introduction Denson G. Fujikawa

General considerations

Chapter 2 Excitotoxic programmed cell death involves caspase-independent mechanisms Ted M. Dawson and Valina L. Dawson

Chapter 3 To survive or to die: how neurons deal with it Yubin Wang, Xiaoning Bi and Michel Baudry

Traumatic Brain Injury

Chapter 4 Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches Edward D. Hall, Indrapal N. Singh and John E. Cebak

Chapter 5 Mitochondrial damage in traumatic CNS injury W. Brad Hubbard, Laurie M. Davis and Patrick G. Sullivan

Chapter 6 Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury Lu-Yang Tao

Focal Cerebral Ischemia

Chapter 7 Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia Nikolaus Plesnila and Carsten Culmsee

Transient global cerebral ischemia

Chapter 8 Apoptosis-inducing factor translocation to nuclei after transient global ischemia Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen and Feng Zhang

Chapter 9 Necroptosis in cerebral ischemia Marta Vieira and Ana Luisa Carvalho

Chapter 10 Histological and elemental changes in ischemic stroke M. Jake Pushie, Vedashree Meher, Nicole Sylvain, Huishu Hou, Annalise Kudryk, Michael B. Kelly and Roland N. Auer

Hypoglycemic neuronal injury

Chapter 11 Hypoglycemic brain damage Roland N. Auer

Seizure-induced neuronal death

Chapter 12 Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis Denson G. Fujikawa

Concluding Remarks Denson G. Fujikawa