Main description:

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity of chemicals and other agents. Permanent mutation in genes and chromosomes can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed in Advances in Mutagenesis Research are: 1. The understanding of the molecular mechanisms leading to mutations, and 2. the prevention of a thoughtless introduction of mutagenic agents into the environment.

Contents:

Micronucleus Assays.- 1 Major Historical Events in Micronucleus Research.- 2 Characteristics, Origin, and Criteria of Micronuclei.- 3 Assay Systems and Methods for Detection of Micronuclei.- 4 Artifacts and Pitfalls.- 5 Characteristics of the Assay System Affecting Micronucleus Yield.- 6 Advantages and Disadvantages of Micronuclei as Assay System.- 7 Application of Micronuclei in Various Fields of Research.- 8 Future Aspects of Micronucleus Research.- References.- Mechanisms of Thermal Radiosensitization Studied in CHO Cells.- 1 Introduction.- 2 Effect of Heat on Radiosensitivity.- 3 DNA Damage.- 4 Effect of Heat on the Activity of Polymerase ss.- 5 Summary.- References.- Alexandra A. Prokofyeva-Belgovskaya (1903-1984) Her Life and Contribution to Cytogenetics.- 1 Bibliographical Notes.- 2 Studying Animal Chromosome Morphology.- 3 Collaboration with C.B. Bridges and H.J. Muller.- 4 Genes and Chromomeres.- 5 Studying Heterochromatic Regions of Drosophila Chromosomes.- 6 The Chromocenter and the X and Y Chromosomes.- 7 Discovery of Telomeric and Intercalary Heterochromatin.- 8 Discovery of High X-Ray Sensitivity of Heterochromatic Regions.- 9 Position Effect of the Variegated Type and the "Heterocyclicity Hypothesis".- 10 Victim of Lysenko.- 11 Restitution.- 12 Human Chromosome Research.- 13 Family and Friends.- 14 The Leader of Cytogenetics in the USSR.- 15 Place in History.- References.