Main description:

During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation.
Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.

Contents:

Editorial: About the series 'Biology of aging and its modulation'; S. Rattan
Preface
1. Free radical production and antioxidant defense: a primer; Nicolle Sitte, Thomas von Zglinicki
2. Oxidative DNA damage and repair - implications for aging; Erling Seeberg
3. Oxidative damage to proteins; Nicolle Sitte
4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies; Reinald Pamplona, Gustavo Barja
5. Genomic instability in human premature aging; Vilhelm A. Bohr, Patricia L. Opresko
6. Oxidative damage, somatic mutations and cellular aging; Rita A. Busuttil, Miguel Rubio, Martijn E.T. Dolle, Judith Campisi, Jan Vijg
7. Mitochondria and aging; Martin Barron, Doug Turnbull
8. Biological clocks in the aging cell; Petra Boukamp
9. Telomeric damage in aging; Thomas von Zglinicki
10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice; Florian L. Muller, James Mele, Holly Van Remmen, Arlan Richardson
11. Non-oxidative modification of DNA and proteins; Alan K. Hipkiss
12. Transcriptional and translational dysregulation during aging; Suresh I.S. Rattan
13. Metabolic regulation of gene silencing and life span; Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair
14. The proteasome in aging; Geraldine Carrard, Bertrand Friguet
15. Aging and lysosomal degradation of cellular constituents; Alexei Terman, Ulf T. Brunk
Index