Main description:

This book is about "Angiogenesis". A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients.

The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer.

New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Contents:

1. Introduction
to Angiogenesis in Normal Physiology. Disease and Malignancy

2. Adenosine triphosphate-binding
cassette (ABC) lipid transporters

3. Angiogenin

4. Angiopoietins

5. Angiotropin

6. C-KIT: tyrosine kinase receptors with
potential to initiate

7. CCND1 and E1

8. Cluster of Differentiation 71 (CD71)

9. Connective Tissue Growth Factor (CTGF)

10. COX10

11. Cysteine-rich 61 (Cyr61)

12. Epidermal growth factor

13. Epidermal growth factor domain-like 7
(EGFL7)

14. Erythropoietin-producing
hepatocellular receptors A: Ephrin A1, Ephrin A2 and Ephrin A3

15. Erythropoietin-producing
hepatocellular receptors B: Ephrin B2, Ephrin B4

16. Ets-1

17. Fibrin

18. Fibroblast
growth factors (Acidic: FGF-1; Basic: FGF-2) and its receptors (FGFR)

19. Fibronectin

20. Granulocyte-Macrophage
and Granulocyte Colony Stimulating Factor (GM-CSF and G-CSF)

21. GAX and HOXA5

22. Heparanase

23. Hepatocyte Growth Factor (HGF)

24. HIF-1

25. Insulin-like growth factor

26. Integrins ( v1 3, v1 5, 8)

27. Interleukins

28. Insulin receptor substrate (IRS1)

29. Iron-sulfur clusters (ISCU)

30. MDM4

31. Matrix Metalloproteinase 2 (MMP2)

32. Monobutyrin

33. Neutrophil activating protein-2 (NAP-2)

34. p27kip1 and p57Kip2 (CDKN1B and CDKN1C)

35. Platelet-derived endothelial cell growth
factor (PDGF)

36. Prolyl hydroxylase domain-2 (PHD-2)

37. Phosphatidylinositol-4, 5-bisphosphate
3-kinase (PIK3Ca)

38. PIK3R2 (p85 ) - Phosphatidylinositol
3-kinase -subunit

39. Platelet-activating factor

40. Placenta growth factor (PlGF)

41. Preproendothelin-1 (PreproET-1)

42. Proliferin

43. Prostaglandins

44. ROS1

45. SIRT1

46. SMAD4 (Mothers against Decapentaplegic
Homolog 4)

47. Sprouty-Related, EVH1 Domain-containing
protein 1 (SPRED-1)

48. Signal
transducer and activator of transcription of 5A and S3 (STAT5 and STATS3)

49. SUFU

50. Tenascins

51. Tissue inhibitor of metalloproteinases 1
and 2 (TIMP-1 and TIMP-2)

52. Tissue factor gene

53. Transforming growth factor and (TGF-
and TGF- )

54. Transforming growth factor beta-receptor
type II (TGF R2)

55. TSP-1

56. Tumour necrosis factor- (TNF- )

57. Urokinase plasminogen activator

58. Vascular Endothelial Growth Factor
(VEGF)

59. Vascular cell adhesion molecule-1
(VCAM-1)

60. Vascular endothelial (VE)-Cadherin

61. Zinc Finger E-Box Binding Homeobox 1
(ZEB1)

62. Miscellaneous
genes involved in Angiogenesis in Normal Physiology, Disease and Malignancy