Main description:

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume II of this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systems.

Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

Contents:

Part I: Basal Ganglia

1. Behavioral Assessment of Genetic Mouse Models of Huntington's Disease

Miriam A. Hickey and Marie-Francoise Chesselet

2. Excitotoxic Lesions of the Rodent Striatum

Mate D Doebroessy, Fabian Buchele, and Guido Nikkhah

3. Combination Lesion Models of MSA

Daniela Kuzdas and Gregor K. Wenning

4. The Role of the Dorsal Striatum in Instrumental Conditioning

Mark Rossi and Henry H. Yin

5. 3-Nitropropionic Acid and Other Metabolic Toxin Lesions of the Striatum

Cesar V. Borlongan and Paul R. Sanberg

6. Functional Assessment of Subcortical Ischemia

Tracy D. Farr and Rebecca C. Trueman

Part II: Neo- and Allo-Cortical Systems

7. Functional Organization of Rat and Mouse Motor Cortex

G. Campbell Teskey and Bryan Kolb

8. Forebrain Circuits Controlling Whisker Movements

Kevin D. Alloway and Jared B. Smith

9. An Approach to Understanding the Neural Circuitry of Saccade Control in the Cerebral Cortex Using Antidromic Identification in the Awake Behaving Macaque Monkey Model

Kevin Johnston and Stefan Everling

10. Photothrombotic Infarction of Caudate Nucleus and Parietal Cortex

Toshihiko Kuroiwa and Richard F. Keep

11. Models of Rodent Cortical Traumatic Brain Injury

Frances Corrigan, Jenna M. Ziebell and Robert Vink

12. The Use of Commissurotomy in Studies of Interhemispheric Communication

Ian Steele-Russell

Part III: Cerebellar and Brain Stem Systems

13. Genetic Models of Cerebellar Dysfunction

Robert Lalonde and Catherine Strazielle

14. Cerebellar Control of Fine Motor Function

Rachel M. Sherrard

15. Cerebellum and Classical Conditioning

Richard F. Thompson

16. Assessments of Visual Function

Ma'ayan Semo, Carlos Gias, Anthony Vugler and Peter John Coffey

17. The Role of the Pedunculopontine Tegmental Nucleus in Motor Disorders

Nadine K. Gut and Philip Winn

Part IV: Spinal Cord Systems

18. Contusion Models of Spinal Cord Injury in Rats

Kelly A. Dunham and Candace L. Floyd

19. Demyelination Models in the Spinal Cord

Paul A. Felts, Damineh Morsali, Mona Sadeghian, Marija Sajic, and Kenneth J. Smith

20. Preparation of Spinal Cord Injured Tissue for Light and Electron Microscopy Including Preparation for Immunostaining

Margaret L. Bates, Raisa Puzis, and Mary Bartlett Bunge

21. Assessing Spinal Cord Injury

Gillian D. Muir and Erin J. Prosser-Loose

22. Precise Finger Movements in Monkeys

Roger Lemon