Main description:

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Feature:

Contributors are at the forefront of scientific discovery

The reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise

Contents:

Section I. Malignant Transformation and Metastasis

BCR-ABL and Cancer
María Pérez-Caro and Isidro Sanchez-Garcia

Angiogenesis and Cancer
Yohei Maeshima

Metastasis: The Evasion of Apoptosis
Christine E. Horak, Jolie L. Bronder, Amina Bouadis, and Patricia S. Steeg

Carcinogenesis: Balance Between Apoptosis and Survival Pathways
Dean G. Tang and Jim Kehrer

Aberrations of DNA Damage Checkpoints in Cancer
Marikki Laiho

c-Myc, Apoptosis and Disordered Tissue Growth
Michael Khan and Stella Pelengaris

Role of Lysophospholipids in Cell Growth and Survival
Ianjun Fang and Sarah Spiegel

Alternative Use of Signaling by the GBP Cytokine in Cell Growth and Cancer Control: From Surveillance to Therapy
Livio Mallucci and Valerie Wells

Control Nodes Linking the Regulatory Networks of the Cell Cycle and Apoptosis
Baltazar D. Aguda, Wee Kheng Yio, and Felicia Ng

Section II. Molecular Basis of Disease Therapy

Regulation of NF B Function: Target for Drug Development
Daniel Sliva and Rakesh Srivastava

5-Fluorouracil: Molecular Mechanisms of Cell Death
D. B. Longley and P. G. Johnston

Apoptosis-Inducing Cellular Vehicles for Cancer Gene Therapy: Endothelial and Neural Progenitors
Gergely Jarmy, Jiwu Wei, Klaus-Michael Debatin, and Christian Beltinger

Apoptosis and Cancer Therapy
Maurice Reimann, and Clemens Schmitt

Coupling Apoptosis and Cell Division Control in Cancer: The Survivin Paradigm
Dario C. Altieri

Clinical Significance of Histone Deacetylase Inhibitors in Cancer
Sharmila Shankar and Rakesh K. Srivastava