Main description:

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the most innovative and current findings. The contributors are at the forefront of scientific discovery.

Contents:

Section I. Kinases and Phosphatases

Significance of Protein Kinase A in Cancer
Maria V. Nesterova and Y. S. Cho-Chung

Protein Kinase C and Cancer
Mary E. Reyland

The Role of PI3K-Akt Signal Transduction in Virus Infection
Samantha Cooray

Cyclin-Dependent Kinase 5: A Target for Neuroprotection?
Frank Gillardon

Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance
James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian, and Richard A. Franklin

MAP Kinases Signaling in Human Diseases
Philippe Roux and J.Blenis

Serine/Threonine Protein Phosphates in Apoptosis
Gro Gausdal, Camilla Krakstad, Lars Herfindal, and Stein Ove Doskeland

Urokinase/Urokinase Receptor-Mediated Signaling in Cancer
Sreerama Shetty, and Steven Idell

Section II. Molecular Basis of Cell Death

Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion
Zheqing Cai and Gregg L. Semenza

Cyclooxygenase-2 Gene Expression: Transcriptional and Posttranscriptional Controls in Intestinal Tumorigenesis
Shrikant Anant and Sripathi M. Sureban

Death Receptors: Mechanisms, Biology and Therapeutic Potential
Sharmila Shankar and Rakesh Srivastava

DNA Damage-Dependent Apoptosis
Tomasz Skorski

The Role of Proteasome in Apoptosis
Peter Low

Apoptosis Induction in T Lymphocytes by HIV
Maria Saveria Gilardini Montani

Inhibitors of Apoptosis Proteins and Caspases
Jai Yu, John Silke and Paul G. Ekert

Intracellular Pathways Involved in DNA-Damage and Repair to Neuronal Apoptosis
Maurizio Memo

The Biology of Caspases
Tasman James Daish and Sharad Kumar