Main description:

This detailed volume reflects the considerable new developments that have taken place in the area of applied neurogenomics, particularly with the rapid progress in next generation sequencing. Beginning with an introduction to the technologies relevant to neurogenomics with an emphasis on next generation sequencing, the book also covers detailed methods relevant to the genomics of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease, targeted sequencing of psychiatric disorders, as well as the role of genomics in the development of personalized neurology. Written in the popular Neuromethods series format, chapters provide the kind of practical description and implementation advice necessary to consistently produce successful results in the lab.

Timely and convenient, Applied Neurogenomics serves as an invaluable reference for researchers working in this expanding, dynamic field.

Contents:

1. An Overview of Methods Used in Neurogenomics and Their Applications

Kewal K. Jain

2. Gene Expression-Based Approaches to Understanding Huntington's Disease and New Tools for the Interpretation of Expression Datasets

Alexandre Kuhn, Alberto Capurro, and Ruth Luthi-Carter

3. Location Analysis and Expression Profiling Using Next Generation Sequencing for Research in Neurodegenerative Diseases

Kristina Gotovac, Fran Borovecki, and Mario Habek

4. RNA Sequencing from Laser Capture Microdissected Brain Tissue to Study Normal Aging and Alzheimer's Disease

Ashley L. Siniard, Jason J. Corneveaux, Matt DeBoth, Monica K. Chawla, Carol A. Barnes, and Matthew J. Huentelman

5. Targeted Re-Sequencing in Psychiatric Disorders

Andre Altmann and Peter Weber

6. Role of Neurogenomics in the Development of Personalized Neurology

Kewal K. Jain