Main description:

This book is a collection of critical reviews about a diverse group of virus families with two features in common: the stable repository of genetic information in each virus is RNA, and each virus modifies and appropriates a particular patch of the eukaryotic cell membrane system to complete its structure. The reviews take the reader from the level of virus genome structure and expression through the quaternary interactions between virus-specified elements and cellular components that cooperate to produce virus particles. There are spectacular illustrations in this volume, but it is much more than a picture gallery. Reading widely in this book can be an effective antidote to overspecialization: in these pages, you are likely to learn much about viruses and about cells that you didn't know before; you'll discover illuminating parallels between diverse virus families; you'll come away with a sharpened awareness of important things that are still to be learned. Memphis, Tenn. , Summer 1984 David W. Kingsbury Preface This book was written at the suggestion of Dr. David W. Kingsbury made at a work shop on viruses organized by the Multiple Sclerosis Society in Aspen, Colorado, U. S. A. , three years ago. Originally, we had thought to focus on the morphological aspects of viral assembly. Later, during our discussions on the process of budding of enveloped RNA viruses, it became evident that we should include biochemical data in our review and correlate them with the structural aspects of virus maturation.

Contents:

1. An Overview of the Assembly of Enveloped RNA Viruses.- I. Introduction.- II. Virus Entry.- III. Virus Genomes.- IV. Synthesis of Virus Components.- Sites of Virus Protein Synthesis.- Synthesis of Virus Glycoproteins.- Glycosylation.- Transport of Virus Glycoproteins.- Cleavage of Precursor Proteins.- Other Post-Translational Modifications.- V. Assembly of Virus Components.- Nucleocapsid (NC) Assembly (Encapsidation).- Structure of NCs.- Sites of Budding.- Early Interactions Between NC and Envelope Proteins.- Virus Budding.- Virus Release.- Defective Assembly.- VI. New Avenues.- 2. Assembly of Rhabdoviridae.- I. Introduction.- II. Molecular Organization.- Replication and Transcription.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- NC Assembly.- Sites of Budding.- Interactions Between NC and Envelope Proteins.- Virus Budding.- Defective Assembly.- V. Virus Release and Organization of the Virion.- 3. Assembly of Paramyxoviridae.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- NC Assembly.- Association of Envelope Proteins.- Interactions Between NC and Envelope Proteins.- Virus Budding.- Defective Assembly.- V. Post-Release Maturation and Organization of the Virion.- 4. Assembly of Orthomyxoviridae.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- NC Assembly.- Interaction Between NC and Envelope Proteins.- Virus Budding.- Defective Assembly.- V. Virus Release and Organization of the Virion.- 5. Assembly of Bunyaviridae.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- V. Virus Release and Organization of the Virion.- 6. Assembly of Arenaviridae.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- NC Assembly.- Virus Budding.- Defective Budding.- V. Organization of the Virion.- 7. Assembly of Coronaviridae.- I. Introduction.- II. Molecular Organization.- Transcription.- Replication.- Virus Proteins.- III. Synthesis, Transport and Processing of Virus Proteins.- IV. Assembly of Virus Components.- NC Assembly.- Interaction of NC and Envelope Proteins and Virus Budding.- Release of Virions from the Cell and Post-Release Maturation.- Defective Assembly.- V. Organization of the Virion.- 8. Assembly of Togaviridae.- Alphaviruses.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Protein Synthesis, Transport and Post-Translational Modifications.- IV. Assembly of Virus Components.- NC Assembly.- Interactions Between NC and Envelope Proteins.- V. Defective Assembly.- VI. Organization of the Virion.- Flaviviruses.- I. Introduction.- II. Molecular Organization.- III. Protein Synthesis, Transport and Post-Translational Modifications.- IV. Assembly of Virus Components.- V. Defective Budding.- VI. Organization of the Virion.- Rubiviruses.- Pestiviruses.- Non-Arthropod-Borne Togaviruses.- Conclusion.- 9. Assembly of Retroviridae.- I. Introduction.- II. Molecular Organization.- Virus Proteins.- III. Intracellular Synthesis of Virus Components.- IV. Assembly of Virus Components.- NC Assembly Occurs Independently from Budding.- NC Assembly Is Coordinated with Budding.- Interactions Between NC and Enveloped Proteins.- Virus Budding.- Virus Release and Post-Release Maturation.- V. Organization of the Virion.- 10. Assembly of Rotaviruses.- I. Introduction.- II. Molecular Organization.- III. Translation, Transport and Processing of Virus Proteins.- IV. Assembly of Virus Components.- NC Assembly.- Virus Budding.- Modification After Budding.- Release of Virions from Infected Cells.- Defective Assembly.- V. Organization of the Virion.- References.