Main description:

This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.

The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice.

This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline.

The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.

Contents:

Part I: Introduction.-

1. Inflammatory bowel disease - more than meets the eye

2. Clinical risk factors - lessons from epidemiology

3. Clinical trial design for biomarker discovery

4. Database/ big data meets real world

5. Patient reported outcomes

Part II: Biomarkers

6. Prognostic vs Predictive

7. Biomarkers for remote monitoring

8. Disease modification

Part IIV: Crohn's disease

9. Luminal Crohn's disease

10. Perianal CD

11. Fibrosis/ strictures in CD

12. Post-op Crohn's disease

Part IV: Ulcerative colitis

13. UC surveillance

14. Acute severe UC

15. Chronic active UC

16. Pouchitis

17. Refractory proctitis

18. Feacal microbiota transplantation

19. Primary sclerosing cholangitis

20. Extraintestinal manifestations of IBD

Part V: Specialised scenarios

21. Pregnancy

22. Nutrition

23. TDM

24. Biomarkers to quantify immune response

25. Drug toxicity

Part VI:Scientific

26. Exposome and diet

27. Microbiota

28. Metabonomics

29. Immunology

30. Genomics

31. Systems Biology in Biomarker research

Part VII: Ideal tools for investigation in the future