Main description:

This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST. International experts provide insight into toxicity markers and surrogate markers. Attention is also given to biomarker assay development, validation, and strategies.

A powerful tool for determining decisions on therapy, selecting drug regimens, monitoring the efficacy of treatment, and performing individualized surveillance, biomarkers represent the forefront of cancer research and treatment. As these technologies become increasingly available for clinical use, this book will be an essential resource for oncologists and translational researchers.

Contents:

Ch. 1: Predictive Markers in Colon Cancer

Armin Gerger, Melissa J. LaBonte, and Heinz-Josef Lenz

Ch. 2: Prognostic Markers in Breast Cancer

Agustin A. Garcia, and Nazish Ahmad

Ch. 3: Predictive Markers in Lung Cancer

Stephen V. Liu, and Barbara J. Gitlitz

Ch. 4: Prostate Cancer: Predictive Markers in Clinical Development

Courtney K. Phillips, and Daniel P. Petrylak

Ch. 5: Biomarkers in GIST

Howard J. Lim, and Charles D. Blanke

Ch. 6: Cytogenetic and Molecular Aberrations as Predictive Biomarkers in Acute Myeloid Leukemia

Steffen Heeg, and Cornelius F. Waller

Ch. 7: Prognostic Markers in Colon Cancer

Janine M. Davies, and Howard L. McLeod

Ch. 8: Markers in Lung Cancer

Edwin Y. Lin, Ravin Rupani, and Barbara J. Gitlitz

Ch. 9: Molecular Markers of Prostate Cancer Outcome

David Ian Quinn, and Gregory P. Swanson

Ch. 10: Prediction of Chemotherapy Toxicities

Pierre Laurent-Puig, Thierry Lecomte, Marie-Anne Loriot, Valerie Boige, and Helene Blons

Ch. 11: Surrogate Markers-The Role of Positron Emission Tomography Scanning

Derek G. Power, and David H. Ilson

Ch. 12: Circulating Tumor Cells as Biomarkers

Amir Goldkorn, Tong Xu, and Stephen V. Liu

Ch. 13: Focus on Personalized Molecular Based Medicine

Lex HT Van der Ploeg, Bud Mishra, Casimir P. Eitner, Jon Burrows, Thomas Wray Tombler, Jr., Vladimir Poponin, Dan J. Knauer, Ilia Ichetovkin, Richard M. Pinnola, Gregory A. Endress, and Patrick Soon-Shiong

Ch. 14: Clinical Validation of Biomarkers

Sumithra J. Mandrekar, and Daniel Sargent

Ch. 15: Regulatory Issues

Maxwell T. Vergo, and Al B. Benson III

Ch. 16: Biomarkers for Safety Assessment and Clinical Pharmacology

Stan Louie, and Jared Russell

Ch. 17: Biomarker Discovery Strategies: DNA, RNA and Protein

Eduardo Vilar, and Josep Tabernero

Ch. 18: Biomarkers For Go/No Go Decisions

Ben Markman, and Josep Tabernero