Published December, 2010
By Jorg Tost and Joerg Tost
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace.

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Published November, 2010
By Mouldy Sioud
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation.

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Published November, 2010
By Mohammed Zaki and Chris Bystroff
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

This book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models.

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Published November, 2010
By Laszlo Otvos
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Due to their high specificity and low toxicity profile, peptides are once more central to the development of new drugs. Comprehensive and up-to-date, this practical volume provides scientists with a clear, concise guide for continuing this vital research.

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Published November, 2010
By David G. Lambert
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

In the first edition of Calcium Signaling Protocols I began by writing "The regula- 2+ tion of intracellular Ca is a common theme presented in many papers over the last 20 2+ or so years and the description of the Ca -sensitive indicator dye fura-2 in 1985 resulted in a massive increase in these types of studies.

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Published November, 2010
By Mukesh Verma
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Population studies and epidemiology facilitate the discovery of genetic and environmental determinants of cancer and the development of new approaches to cancer control and prevention, therefore they play a central role in the creation of health policies.

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Published November, 2010
By Alexander E. Kalyuzhny
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Highlights include dual-color and multiplex ELISPOT assays, use of the ELISPOT assay on feline lymphocytes, standardization of the ELISPOT procedure, and combining the ELISPOT assay with immunohistochemistry.

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Published November, 2010
By X. Johné Liu
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

A collection of standard and cutting-edge techniques for using Xenopus oocytes and oocytes/egg extracts to reconstitute biological and cellular processes.

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Published November, 2010
By Glyn Stacey and John G. Day
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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It includes novel approaches and protocols that were not preservable when the first edition was published.The book begins with a discussion of long term ex situ conservation of biological resources, the role of biological resource centers, and fundamental principles of freeze-drying and cryopreservation.

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Published November, 2010
By John Howl
Publisher: Springer (Humana Press Inc.)
Series: Methods in Molecular Biology
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Availability: Available

Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases.

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