Main description:

Originally published in 1994, this was the first volume to look in depth at the way the brain responds to trauma and subsequently integrates and influences behavioural, metabolic, neurohumoral, cardiovascular and immune functions. At the time, the role of the brain in the control and integration of the responses to injury and infection was becoming increasingly clear. It had been established that some of these responses, such as fever and neuroendocrine changes, responded to the direct influence of the central nervous system. These, and other advances, provided fresh insights into this area and formed a basis for the more effective understanding and clinical management of trauma patients. In this volume, the authors, all international authorities in their fields, discuss data from experimental and clinical studies and considered the implications of these findings for the treatment of the trauma patient.

Contents:

1. Introduction N. J. Rothwell; 2. Overview of responses to injury B. Stonar; 3. Experimental approaches to the study of CNS control of responses to injury N. J. Rothwell and R. Little; 4. CNS control and neural mediations of immune responses and inflammation D. Payan; 5. Neurohormonal control of cytokines during injury I. Berczi; 6. Brain regions involved in modulation of immune responses P. Neveu; 7. Psychological and neurobiological consequences of trauma C. Nemeroff; 8. CNS control of sickness behaviour Robert Dantzer; 9. Psychological and behavioural aspects of pain H. Ursin; 10. Central control of cardiovascular responses to injury R. Little and E. Kirkman; 11. Endocrine/neuroendocrine responses to trauma F. Berkenbosch; 12. Central control of the metabolic and thermoregulatory responses to injury N. J. Rothwell; 13. Central control of pain R. W. Clarke; Index.