Main description:

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain.

Contents:

1. Introduction and overview

Part I Physiology and principles for brain targeting drug delivery

2. Anatomy and physiology of blood-brain barrier

3. Recent progress in blood-brain barrier transportation research

4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery

Part II Nanoparticles-based brain targeting delivery strategies

5. Receptor-mediated transportation through BBB

6. Carrier-mediated transportation through BBB

7. Brain drug delivery by adsorption-mediated transcytosis

8. Efflux pump inhibition to enhance brain targeting delivery

9. Physically open BBB

10. Nanoparticle systems for nose-to-brain delivery

11. Brain local delivery strategy

Part III Nanoparticles-based brain targeting delivery for CNS disorder management

12.Glioma targeted delivery systems

13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases

14. Savaging brain ischemia by increasing brain uptake of neuroprotectants

Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery

15. Neurotoxicity concern about the brain targeting delivery systems

16. The intra-brain distribution of brain targeting delivery systems

17. The elimination of brain-targeted nanomaterials

18. Perspective on brain targeting drug delivery systems