Main description:

This volume explores the latest models and techniques used to study brain tumor biology. Chapters in this book are organized into four sections: in vivo models, ex vivo models, treatments in mice, and clinical imaging. Some of the topics covered in this book are in vivo preclinical models of lower-grade gliomas, medulloblastoma, and brain metastases; ex vivo methods for glioblastoma patient-derived cell lines and organotypic brain cultures for metastasis; in vivo treatments of preclinical models that assess neurological function, dynamic immunotherapy, and neurological impacts of brain irradiation; and clinical imaging and modeling, such as biomechanics and vascular perfusion. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and practical, Brain Tumors is a valuable resource that will help readers understand the heterogeneity of the techniques used to study the complexity of brain tumors.

Contents:

Series Preface...Acknowledgements...Preface...Table of Contents...Contributing Authors...
Part I In Vivo Models
1. Mouse Models of Diffuse Lower-Grade Gliomas of the AdultSofia Archontidi, Sandra Joppe, Yanis Khenniche, Chiara Bardella, and Emmanuelle Huillard
2. In Vivo Medulloblastoma ModelingLiliana Mirabal-Ortega, Magalie Larcher, Morgane Morabito, Chloe Foray, Bertrand Duvillie, Alain Eychene, and Celio Pouponnot
3. In Vivo Models of Brain MetastasesChristina S. Wong
4. Intravital Imaging of Brain TumorsCathy Pichol-Thievend, Boris Julien, Oceane Anezo, Beatrice Philip, and Giorgio Seano
Part II Ex Vivo Models
5. Glioblastoma Patient-Derived Cell Lines: Generation of Non-Adherent Cellular Models from Brain TumorsJoris Guyon, Tiffanie Chouleur, Andreas Bikfalvi, and Thomas Daubon
6. Organotypic Brain Cultures for Metastasis ResearchLucia Zhu and Manuel Valiente
7. Human Glioblastoma Organoids to Model Brain Tumor Heterogeneity Ex VivoW. Dean Pontius, Lisa C. Wallace, Katrina Fife, and Christopher G. Hubert
8. In Vitro Mechanobiology of Glioma: Mimicking the Brain Blood Vessels and White Matter Tracks Invasion PathsPascale Monzo, Michele Crestani, and Nils C. Gauthier
Part III Treatments in Mice
9. Assessing Neurological Function in Brain Tumor Mouse ModelXing Gao, Limeng Wu, Raquel D. Thalheimer, Jie Chen, Yao Sun, Grace Y. Lee, Scott R. Plotkin, and Lei Xu
10. Dynamic Immunotherapy Study in Brain Tumor-Bearing MiceLuiz Henrique Medeiros Geraldo, Yunling Xu, and Thomas Mathivet
11. Experimental and Preclinical Tools to Explore the Main Neurological Impacts of Brain Irradiation: Current Insights and PerspectivesLaura Mouton, Monica Ribeiro, Fawzi Boumezbeur, Denis Le Bihan, Marc-Andre Mouthon, Damien Ricard, Francois Boussin, and Pierre Verrelle
Part IV Clinical Imaging
12. Mechano-Biological Features in the Patient-Specific Computational Model of GlioblastomaFrancesco Acerbi, Abramo Agosti, Jacopo Falco, Stefano Marchesi, Ignazio G. Vetrano, Francesco DiMeco, Alberto Bizzi, Paolo Ferroli, Giorgio Scita, and Pasquale Ciarletta
13. Magnetic Resonance Imaging for Quantification of Brain Vascular PerfusionLine Brennhaug Nilsen and Kyrre Eeg Emblem
14. MRI Morphometry in Brain Tumors: Challenges and Opportunities in Expert, Radiomic, and Deep-Learning Based AnalysesMarco C. Pinho, Pallavi Tiwari, Kaustav Bera, and Niha Beig
Subject Index List...