Main description:

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics, tumor heterogeneity, whole genome, exome and transcriptome sequencing, epigenomics, and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more.

Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed.

Key Features:

Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types
Explains what mutations are, what tests are needed, and how to interpret the results
Provides information on FDA-approved targeted therapies that are being used in the clinic
Covers different sequencing platforms and technologies and how they perform in research settings
Includes access to the fully-searchable downloadable eBook

Contents:

Chapter One: Introduction to Cancer Genomics
Deepali Jain, Brett Herzog, and Leonard B. Maggi, Jr.
Chapter Two: Tumor Mutational Profiling by Next Generation Sequencing
Samantha N. McNulty, Latisha Love-Gregory, and Jonathan W. Heusel
Chapter Three: Bioinformatics: What a Clinician Should Know
Irena Lanc and Arpad Danos
Chapter Four: Tumor Heterogeneity
Alex H. Wagner, Kilannin Krysiak, Katie M. Campbell, and Erica K. Barnell
Chapter Five: Epigenetics Alterations in Cancer
Erica C. Pehrsson, Hyo Sik Jang, and Ting Wang
Chapter Six: Cell-Free DNA in Cancer Diagnosis and Follow-Up
Bruna Pellini Ferreira and Daniel Morgensztern
Chapter Seven: Optimizing Targeted Therapies Using Next Generation Sequencing
Brett Herzog and Saiama N. Waqar