Main description:

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.

Contents:

Preface

Part I. The Biology of Cancer Stem Cells

Chapter 1

Cancer Stem Cells: A Quick Walk through the Concepts

Katayoon Pakravan, Mohammad Amin Mahjoub, Sadegh Babashah

Chapter 2

Cellular Plasticity, Cancer Stem Cells and Metastasis

Paola Ferrari, Andrea Nicolini

Chapter 3

Cytokine Networks and Cancer Stem Cells

Clifford Liongue, Alister C Ward, Wei Duan, Sarah Shigdar

Chapter 4

Implications of CXCR4/CXCL12 Interaction for Cancer Stem Cell Maintenance and Cancer Progression

Claudia Peitzsch, Monica Cojoc, Ina Kurth, Anna Dubrovska

Chapter 5

Non-coding RNAs in Cancer and Cancer Stem Cells

Ryou-u Takahashi, Hiroaki Miyazaki, Takahiro Ochiya

Chapter 6

Self-renewal Pathways in Mammary Stem Cells and Carcinogenesis

Lu Deng, Jiahui Xu, Dong Wang, Suling Liu

Part II. Cancer Stem Cells in Human Malignancies

Chapter 7

Breast Cancer Stem Cells

Giorgia G. Silveira, Joao Paulo Oliveira-Costa, Alfredo Ribeiro-Silva

Chapter 8

Lung Cancer Stem Cells

Gavitt A. Woodard, David M. Jablons

Chapter 9

Colorectal Cancer Stem Cells

Pratima Nangia-Makker, Yingjie Yu, Lulu Farhana, Kulsoom Ahmed, Adhip P.N. Majumdar

Chapter 10

Pancreatic Cancer Stem Cells

Deepak Ray, Reyhaneh Khoshchehreh, Alexandra Aicher, Christopher Heeschen

Chapter 11

Glioblastoma Cancer Stem Cells

Luca Persano, Alessandro Della Puppa, Elena Porcu, Francesca Maule, Giampietro Viola

Chapter 12

Head and Neck Cancer Stem Cells

Chiara Bianchini, Andrea Ciorba

Chapter 13

Leukemic and Lymphoid Stem Cells

Michael W. Becker, Kristen M. O'Dwyer

Chapter 14

Leukemic Stem Cells in Acute Lymphoblastic Leukemia

Ugo Testa

Part III. Novel Approaches for Targeting Cancer Stem Cells

Chapter 15

Targeting Key Stemness-Related Pathways in Human Cancers

Kyrsta M Coyle, Margaret L Thomas, Mohammad Sultan, Paola Marcato

Chapter 16

Targeting Cancer Stem Cells and the Tumor Microenvironment

Alice Turdo, Matilde Todaro, Giorgio Stassi

Chapter 17

Cancer Stem Cells and Chemoresistance: Strategies to Overcome Therapeutic Resistance

Margaret L Thomas, Krysta M Coyle, Mohammad Sultan, Paola Marcato

Chapter 18

Cancer Stem Cells and Tumor Radioresistance

Aadel A Chaudhuri, Michael S Binkley, Maximilian Diehn

Chapter 19

Therapeutic Implications of Cancer Stem Cell: Challenges and Opportunities in Translational Studies

Chunguang Yang, Kunlin Jin, Yue Zhang, Hong Sun, William C Cho

Index