Main description:

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications.

This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.

Contents:

Chapter 1. Introduction

Nomenclature, Structure, and Stability

Generation of Carbocations

The Non-Classical Ion Controversy

Electrophilic Addition to Alkenes

Electrophilic Aromatic Substitution

Elimination reactions

Rearrangement Reactions of Carbocations

References

Chapter 2. Nucleophilic Aliphatic Substitution - SN1

Introduction

-Activated Alcohols-Bronsted Acids

-Activated Alcohols-Lewis Acids

Alkylation of Aldehydes and Ketones

Glycosylation

Friedel-Crafts Alkylation and Acylation

Electrophilic Fluorination Using Fluoronium Ion

Miscellaneous SN1-related Reactions

References

Chapter 3. Nucleophilic Aliphatic Substitution - SN2

Construction of Quaternary Stereogenic Centers

Sulfur Chemistry

Organometallic Chemistry

Macrocyclization

Glycosylation

Nucleoside Analogues

N-Alkylation

Cyclotetraphosphazenes

Conformationally Locked Tetrahydropyran Ring

The Ionic Liquid Effect

Silver Chemistry

References

Chapter 4. Electrophilic Addition to Alkenes

Introduction

Cyclopropanation

Hydroboration/Oxidation

The Pauson-Khand Reaction

Prins Reaction

Schmidt Reaction

Halogenation

Oxymercuration/Reduction

Epoxidation

Gold-Catalyzed Alkyne Hydration

Conclusion

References

Chapter 5. Electrophilic Aromatic Substitution

Introduction

Nitration

Halogenation

Friedel-Crafts Alkylation

Friede