Main description:

In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.

Contents:

Part I. Cardiac Markers in Clinical Practice

Early Detection of Myocardial Necrosis in the Emergency Setting and Utility of Serum Biomarkers in Chest Pain Unit Protocols
Andra L. Blomkalns and W. Brian Gibler

Management of Acute Coronary Syndromes
Constantine N. Aroney and James A. de Lemos

Evolution of Cardiac Markers in Clinical Trials
Alexander S. Ro and Christopher R. deFilippi

Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers: Practice and Promise
Robert H. Christenson and Hassan M. E. Azzazy

The Use of Cardiac Biomarkers to Detect Myocardial Damage Induced by Chemotherapeutic Agents
Eugene H. Herman, Steven E. Lipshultz, and Victor J. Ferrans

The Use of Biomarkers to Provide Diagnostic and Prognostic Information Following Cardiac Surgery
Jesse E. Adams, III

Part II. Clinical Use for Cardiac Troponins

Cardiac Troponins: Exploiting the Diagnostic Potential of Disease-Induced Protein Modifications
Ralf Labugger, D. Kent Arrell, and Jennifer E. Van Eyk

Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients
Fred S. Apple

Cardiac-Specific Troponins Beyond Ischemic Heart Disease
David Morrow

Part III. Analytical Issues for Cardiac Markers

Antibody Selection Strategies in Cardiac Troponin Assays
Alexei Katrukha

Interferences in Immunoassays for Cardiac Troponin
Kiang-Teck J. Yeo and Daniel M. Hoefner

Cardiac Marker Measurement by Point-of-Care Testing
Paul O. Collinson

Standardization of Cardiac Markers
Mauro Panteghini

Analytical Issues and the Evolution of Cutoff Concentrations for Cardiac Markers
Alan H. B. Wu

Part IV. Early Cardiac Markers of Myocardial Ischemia and Risk Stratification

Rationale for the Early Clinical Application of Markers of Ischemia in Patients with Suspected Acute Coronary Syndromes
Robert L. Jesse

Ischemia-Modified Albumin, Free Fatty Acids, Whole Blood Choline, B-Type Natriuretic Peptide, Glycogen Phosphorylase BB, and Cardiac Troponin
Alan H. B. Wu, Peter Crosby, Gary Fagan, Oliver Danne, Ulrich Frei, Martin Moeckel, and Joseph Keffer

C-Reactive Protein for Primary Risk Assessment
Gavin J. Blake and Paul M. Ridker

Prognostic Role of Plasma High-Sensitivity C-Reactive Protein Levels in Acute Coronary Syndromes
Luigi M. Biasucci, Antonio Abbate, and Giovanna Liuzzo

Preanalytic and Analytic Sources of Variations in C-Reactive Protein Measurement
Thomas B. Ledue and Nader Rifai

Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification
Jan F. C. Glatz, Roy F. M. van der Putten, and Wim T. Hermens

Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein in Patients with Coronary Artery Disease
Paul Holvoet

Part V. Cardiac Markers of Congestive Heart Failure

Pathophysiology of Heart Failure
Johannes Mair

B-Type Natriuretic Peptide: Biochemistry and Measurement
Jeffrey R. Dahlen

B-Type Natriuretic Peptide in the Diagnoses and Management of Congestive Heart Failure
Ramin Tabbibizar and Alan Maisel

Monitoring Efficacy of Treatment with Brain Natriuretic Peptide
Emil D. Missov and Leslie W. Miller

N-Terminal Pro-B-Type Natriuretic Peptide
Torbjorn Omland and Christian Hall

Part VI. Role of Infectious Diseases and Genetics in Heart Disease

Infectious Diseases in the Etiology of Atherosclerosis and Acute Coronary Syndromes: Focus on Chlamydia pneumoniae
Martin Moeckel

Polymorphisms Related to Acute Coronary Syndromes and Heart Failure: Potential Targets for Pharmacogenomics
Alan H. B.