Main description:

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Contents:

The Mechanosensory Heart.- Origin of Mechanotransduction.- The Role of the Sarcomere and Cytoskeleton in Cardiac Mechanotransduction.- Mechanoelectric Transduction/Feedback: Physiology and Pathophysiology.- Mechanotransduction in Cardiac Remodeling and Heart Failure.- Second Messenger Systems Involved in Heart Mechanotransduction.- The Role of Adrenoceptors in Mechanotransduction.- Intracellular Signaling Through Protein Kinases in Cardiac Mechanotransduction.- Mechanotransduction of the Endocrine Heart.