Main description:

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions.

Contents:

1. The Cardiovascular Physiology and Pharmacology of Endothelin-1 2. Vascular Pharmacology of Epoxyeicosarienoic Acids 3. Prostaglandins in Action: Indispensable Roles of Cyclooxygenase-1 and 2 in Endothelium-dependent Contractions 4. TP Receptors and Oxidative Stress: Hand in Hand from Endothelial Dysfunction to Atherosclerosis 5. Regulation of Endothelial Cell Tetrahydrobiopterin: Pathophysiological and Therapeutic Implications 6. Polyphenol-Induced Endothelium-Dependent Relaxations: Role of NO and EDHF 7. Organic Nitrates and Nitrate Tolerance - State of the Art and Future Developments 8. Vascular Actions of Adipokines: Molecular Mechanism and Therapeutic Intervention 9. Cardiovascular Effects of Erythropoietin: An Update