Published December, 2020
By Marc Buyse, Shigeyuki Matsui and Richard Simon
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book offers statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics. The book explains how to identify molecular biomarkers using DNA microarrays, validate the developed biomarkers, and confirm

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Published December, 2020
By Sandeep M Menon, Kerry B. Barker, Siyan Xu, Ralph B. D'Agostino, Sr., Bo Jin, PhD, Sr. D'Agostino and PhD Jin
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various

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Published December, 2020
By Monika Maya Wahi, Peter Seebach and Monika Wahi
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book discusses how to do routine health data analysis, typically done in SAS, in R. It assumes that the audience has some experience in this area. Many SAS users want to try R, but R developers have not focused on health data analysis cookbooks. This book will allow them to add R to their analytic skills toolbox.

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Published December, 2020
By Ronald B. Geskus
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This practical and thorough book explains when and how to use models and techniques for the analysis of competing risks and intermediate states. It covers the most recent insights on estimation techniques and discusses in detail how to interpret the obtained results. Each chapter includes standard exercises; a software section on SAS, Stata, and

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Published December, 2020
By Ross L. Prentice and Shanshan Zhao
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Though much has been written on multivariate failure time data analysis methods, a unified approach to this topic has yet to be communicated. This book aims to fill that gap through a novel focus on marginal hazard rates and cross ratio modeling. Readers will find the content useful for instruction, for application in collaborative research and

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Published December, 2020
By Mohamed M. Shoukri
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Presenting in depth discussions of various statistical models and methods needed for the analysis of medical, biological and biostatistics data, this book emphasizes the analysis of data when normal distribution assumptions are not tenable. It provides detailed explanations in situations when data are naturally clustered in groups, whereby the I

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Published December, 2020
By Daniel Commenges and Helene Jacqmin-Gadda
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

This book presents statistical models and methods for the analysis of longitudinal data. It focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. The book also explores the possibility of unifying these models through a stochastic process point of

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Published December, 2020
By Shein-Chung Chow
Publisher: Taylor & Francis (CRC Press)
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Availability: Available

Focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It will cover current issues, and recent development in analytical similarity assessment.

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Published December, 2020
By Elias Moreno, Francisco Jose Vazquez-Polo and Miguel Angel Negrin-Hernandez
Publisher: Taylor & Francis (CRC Press)
Rating:
Availability: Available

This book deals with the statistical analysis of the cost-effectiveness of medical treatments.

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Published December, 2020
By Wei Zhao, Harry Yang, Jianchun Zhang and Binbing Yu
Publisher: Taylor & Francis (CRC Press)
Rating:
Availability: Available

A critical issue in the development of biologics, immunogenicity can cause early termination or limited use of the products if not managed well. This book shows how to use robust statistical methods for detecting, quantifying, assessing, and mitigating immunogenicity risk. Along with covering regulatory requirements, the authors discuss statisti

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