Main description:

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

Contents:

Introduction to Cellular Drug Delivery: Present Realities and Future Prospects
Kinam Park

Part I. Fundamentals of Cell Biology and Cellular Drug Delivery

Cellular Structure, Function, and Membrane Transport
Emily Ware, D. Robert Lu, and Svein Oie

Cellular Growth, Development, and Defensive Response
Yan Huang, Guangliang Pan, Svein Oie, and D. Robert Lu

Part II. Principles of Cellular Drug Delivery

Augmentation of Cell-Mediated Immunity to Virus
Erica L. Woodahl and Rodney J. Y. Ho

Development of Nonviral DNA Delivery Systems
Hans E. J. Hofland, Frank L. Sorgi, and Edward G. Spack

Nucleic Acid Cellular Delivery
Wu Xiao, Chun Zhang, Preeti Yadava, and Jeffrey Hughes

TAT and TAT-Like Peptides for Protein Transduction and Intracellular Drug Delivery
Min Jae Lee, Dexi Liu, Guisheng Zhang, and Xiang Gao

Carrier-Mediated Mechanisms for Cellular Drug Transport
Antara Banerjee, Jeffrey S. Johnston, and Peter W. Swaan

ABC Transporter Proteins and Cellular Drug Resistance: P-Glycoprotein and Analogous Transporters
William W. Johnson

Human Intestinal Cellular Characteristics and Drug Permeability
James E. Polli, Anand Balakrishnan, and Paul R. Seo

Targeted Drug Delivery to Tumor Cells Using Colloidal Carriers
Sushma Kommareddy and Mansoor Amiji

Biological Protein Nanostructures and Targeted Drug Delivery
Guangliang Pan, Svein Oie, and D. Robert Lu

Part III. Practice and Technology of Cellular Drug Delivery

Formulation Considerations for DNA-Based Therapeutics
Thomas J. Anchordoquy, Taylor K. Armstrong, Marion d.C. Molina, S. Dean Allison, Ye Zhang, Mayank M. Patel, Yvonne K. Lentz, and Gary S. Koe

Cationic Microparticles and Emulsions As Effective Delivery Systems for Immune Stimulatory CpG DNA
Derek T. O'Hagan, Manmohan Singh, andJeffrey B. Ulmer

Transdermal Delivery of Antisense Oligonucleotides
WeiQi Lin, Michel Cormier, and Peter E. Daddona

Fc Receptor Targeting With Recombinant Immunoglobulins and Immunoglobulin Formulations
Adrian Bot and Dan Smith

Antibody-Mediated Drug Delivery in Cancer Therapy
Zhenping Zhu and Daniel J. Hicklin

Automated Property Profiling for Cellular Drug Delivery
Edward H. Kerns and Li Di

Index