Main description:

This book provides a comprehensive overview of pediatric oncology, discussing drug therapy and treatment in children under the age of 1 year. It is the first volume to focus on chemotherapy in newborns and infants, especially the daily clinical practice and treatment protocols. Intended as a practical manual, it addresses all the major topics related to pediatric oncology in an accessible and easy-to-use format. It examines topics in pediatric oncology therapeutics, including drug metabolism, excretion, toxicity, drugs that can be used for each week or month of the patient's life, dose adjustment and treatment protocols.Chemotherapy in Neonates and Infants focuses on the safe treatment of children in the first year of life, and is aimed at pediatric oncology/hematology institutions, clinics and departments. It is particularly valuable for researchers, pediatric oncology physicians, pediatric and neonatology physicians, oncology pharmacists and the other healthcare professionals directly involved in the chemotherapy of neonates and infants.

Contents:

1. Introduction 1.1. Differences of drug metabolism in neonates 1.2. Differences of drug metabolism in infants 1.3. Chemotherapy in neonates 1.4. Chemotherapy in infants 1.5. Statistics of the diseases in neonates and infants in each continent 1.6. Statistics of Oncohematology treatment of neonates and infants2. Protocols used in chemotherapy treatment of neonates and infants 3. Pharmacokinetics of Chemotherapy Drugs in Neonates and Infants 3.1. Absorption of chemotherapy in Neonates and Infants 3.2. Drug Binding and Distribution by Proteins 3.2.1. Binding Proteins in Neonates 3.2.2. Binding Proteins in Infants 3.2.3. Transport Proteins in Neonates 3.2.4. Transport Proteins in Infants 3.3. Biotransformation by Enzyme Complexes 3.3.1. Enzyme Complexes in Neonates 3.3.2. Enzyme Complexes in Infants 3.3.3. Enzymes which metabolizes chemotherapy - Which can be used when 3.4. Excretion of Hydrosoluble Drugs 3.4.1. Creatinine clearance in Neonates 3.4.2. Creatinine clearance in Infants 3.4.3. pH urinary in Neonates and Infants 3.4.4. Tubular Secretion 3.4.5. Urinary flow in Neonates and Infants 3.5. Excretion of Liposoluble Drugs4. Pharmacodinamics of Chemotherapy Drugs in Neonates and Infants 4.1. Receptors of Chemotherapy Drugs in Neonates 4.2. Receptors of Chemotherapy Drugs in Infants 4.3. Signaling in Neonates 4.4. Signaling in Infants 4.5. Therapeutic Index in Neonates and Infants 4.6. Dose-Response Relation in Neonates 4.7. Dose-Response Relation in Infants5. List of Chemotherapy Drugs in Neonates and Infants 6. List of Adjuvant Drugs in Chemotherapy of Neonates and Infants 7. Drug Interactions in Neonates and Infants
8. Toxicity
9. Tumor Lysis in Neonates and Infants
10. Chemotherapy in Neonates and Infants with Congenital Diseases 11. Bone Marrow Transplantation in Neonates and Infants
11.1. Bone Marrow Transplantation in Neonates 11.2. Bone Marrow Transplantation in Infants12. Body Surface of Neonates13. Body Surface of Infants14. Glossary