Main description:

Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance.

Key Features:

The book presents historical content from the time of discovery for each family of ligands.
Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions
Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production
Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations

Contents:

Contents

Preface......................................................................................................................vii

Editor.........................................................................................................................ix

List of Contributors....................................................................................................xi

Abbreviations and Acronyms................................................................................. xiii

Chapter 1 Chiral Bidentate Heterodonor P-Oxazoline Ligands ...........................1

Maria Biosca, Jordi Faiges, Montserrat Dieguez,

and Oscar Pamies

Chapter 2 Chiral Bidentate Heterodonor P-N-Other-Ligands............................. 33

Pep Rojo, Marina Bellido, Xavier Verdaguer, and Antoni Riera

Chapter 3 Chiral Bidentate Heterodonor P,S/O Ligands..................................... 81

Jessica Margalef and Miquel A. Pericas

Chapter 4 Chiral Bidentate Heterodonor P-P' ligands....................................... 109

Antonio Pizzano

Chapter 5 Chiral Tridentate-Based Ligands...................................................... 167

Uchchhal Bandyopadhyay, Basker Sundararaju, Rinaldo Poli,

and Eric Manoury

Chapter 6 Chiral N-Heterocyclic Carbene-Based Ligands................................ 195

Vincent Cesar, Christophe Fliedel, and Agnes Labande

Chapter 7 Chiral Monophosphorus Ligands...................................................... 233

Wenjun Tang, Feng Wan, and He Yang

Chapter 8 Solvent-Oriented Ligand and Catalyst Design in Asymmetric

Catalysis - Principles and Limits ..................................................... 261

Armin Boerner

Index....................................................................................................................... 315