Main description:

Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Contents:

Section I: Natural History of Chronic HCV

Ch. 1- Epidemiology of Chronic HCV

Gary Davis

Ch. 2- Acute HCV

Katja Deterding

Heiner Wedemeyer

Michael P. Manns

Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis

Xavier Forns

Ch. 4- Chronic HCV and Steatosis

Dawn McDowell Torres

Stephen A. Harrison

Ch. 5- Chronic HCV and Hepatocellular Carcinoma

Morris Sherman

Ch. 6- Extrahepatic Manifestations of Chronic HCV

Antonio Craxi

Vincenza Calvaruso

Ch. 7- Chronic HCV and HIV Co-infection

Patrick Ingiliz

Maud Lemoine

Yves Benhamou

Ch. 8- Chronic HCV in Patients with Renal Disease

Paul Martin

Fabrizio Fabrizi

Ch. 9- Does Treatment Alter the Natural History of Chronic HCV

Bruce Bacon

Fasiha Kanwal

Section II: Treatment of Chronic HCV with Interferon Based Therapy

Ch. 10- Treatment with Interferon and Ribavirin

Stuart Roberts

William Kemp

Ch. 11- Immune Modulators and Other Agents

Edgar D. Charles

Ira M. Jacobson

Ch. 12- Measuring HCV RNA and Assessing Virologic Response

Jean-Michel Pawlotsky

Ch. 13- Response Guided Therapy

Mitchell Shiffman

Ch. 14- Managing the Side Effects of Therapy

Curtis Cooper

Ch. 15- The Genetics of Virologic Response

Andrew J Muir

Alison B. Jazwinski

Ch. 16- Maintenance Therapy with Peginterferon

Nezem Afdahl

Raza Malik

Section III: Anti-viral Therapy for Chronic HCV

Ch. 17- Anti-viral Targets in HCV

Bernd Kronenberger

Stefan Zeuzem

Ch. 18- Mutations and the Development of Anti-viral Resistance

Geoffrey Dusheiko

Anna Maria Geretti

Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy

Patrick Marcellin

Nathalie Boyer

Tarik Asselah

Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin

Ed Gane

Ch. 21- Maintenance Therapy with Oral Anti-viral Agents

Donald M. Jensen

Andrew Aronsohn

Section IV: Liver Transplantation for Chronic HCV

Ch. 22- Natural History of Chronic HCV after Liver Transplantation

Michael Charlton

Bart J. Veldt

Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV

Robert Brown

Elizabeth C. Verna

Ch. 24- Treating HCV Prior to Liver Transplantation

Greg Everson

Alvaro Martinez-Camacho

Brett E. Fortune

Ch. 25- Treating HCV after Liver Transplantation

Sammy Saab

Michael Chang

Hubert Sung

Ch. 2- Acute HCV

Katja Deterding

Heiner Wedemeyer

Michael P. Manns

Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis

Xavier Forns

Ch. 4- Chronic HCV and Steatosis

Dawn McDowell Torres

Stephen A. Harrison

Ch. 5- Chronic HCV and Hepatocellular Carcinoma

Morris Sherman

Ch. 6- Extrahepatic Manifestations of Chronic HCV

Antonio Craxi

Vincenza Calvaruso

Ch. 7- Chronic HCV and HIV Co-infection

Patrick Ingiliz

Maud Lemoine

Yves Benhamou

Ch. 8- Chronic HCV in Patients with Renal Disease

Paul Martin

Fabrizio Fabrizi

Ch. 9- Does Treatment Alter the Natural History of Chronic HCV

Bruce Bacon

Fasiha Kanwal

Section II: Treatment of Chronic HCV with Interferon Based Therapy

Ch. 10- Treatment with Interferon and Ribavirin

Stuart Roberts

William Kemp

Ch. 11- Immune Modulators and Other Agents

Edgar D. Charles

Ira M. Jacobson

Ch. 12- Measuring HCV RNA and Assessing Virologic Response

Jean-Michel Pawlotsky

Ch. 13- Response Guided Therapy

Mitchell Shiffman

Ch. 14- Managing the Side Effects of Therapy

Curtis Cooper

Ch. 15- The Genetics of Virologic Response

Andrew J Muir

Alison B. Jazwinski

Ch. 16- Maintenance Therapy with Peginterferon

Nezem Afdahl

Raza Malik

Section III: Anti-viral Therapy for Chronic HCV

Ch. 17- Anti-viral Targets in HCV

Bernd Kronenberger

Stefan Zeuzem

Ch. 18- Mutations and the Development of Anti-viral Resistance

Geoffrey Dusheiko

Anna Maria Geretti

Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy

Patrick Marcellin

Nathalie Boyer

Tarik Asselah

Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin

Ed Gane

Ch. 21- Maintenance Therapy with Oral Anti-viral Agents

Donald M. Jensen

Andrew Aronsohn

Section IV: Liver Transplantation for Chronic HCV

Ch. 22- Natural History of Chronic HCV after Liver Transplantation

Michael Charlton

Bart J. Veldt

Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV

Robert Brown

Elizabeth C. Verna

Ch. 24- Treating HCV Prior to Liver Transplantation

Greg Everson

Alvaro Martinez-Camacho

Brett E. Fortune

Ch. 25- Treating HCV after Liver Transplantation

Sammy Saab

Michael Chang

Hubert Sung

Ch. 2- Acute HCV

Katja Deterding

Heiner Wedemeyer

Michael P. Manns

Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis

Xavier Forns

Ch. 4- Chronic HCV and Steatosis

Dawn McDowell Torres

Stephen A. Harrison

Ch. 5- Chronic HCV and Hepatocellular Carcinoma

Morris Sherman

Ch. 6- Extrahepatic Manifestations of Chronic HCV

Antonio Craxi

Vincenza Calvaruso

Ch. 7- Chronic HCV and HIV Co-infection

Patrick Ingiliz

Maud Lemoine

Yves Benhamou

Ch. 8- Chronic HCV in Patients with Renal Disease

Paul Martin

Fabrizio Fabrizi

Ch. 9- Does Treatment Alter the Natural History of Chronic HCV

Bruce Bacon

Fasiha Kanwal

Section II: Treatment of Chronic HCV with Interferon Based Therapy

Ch. 10- Treatment with Interferon and Ribavirin

Stuart Roberts

William Kemp

Ch. 11- Immune Modulators and Other Agents

Edgar D. Charles

Ira M. Jacobson

Ch. 12- Measuring HCV RNA and Assessing Virologic Response

Jean-Michel Pawlotsky

Ch. 13- Response Guided Therapy

Mitchell Shiffman

Ch. 14- Managing the Side Effects of Therapy

Curtis Cooper

Ch. 15- The Genetics of Virologic Response

Andrew J Muir

Alison B. Jazwinski

Ch. 16- Maintenance Therapy with Peginterferon

Nezem Afdahl

Raza Malik

Section III: Anti-viral Therapy for Chronic HCV

Ch. 17- Anti-viral Targets in HCV

Bernd Kronenberger

Stefan Zeuzem

Ch. 18- Mutations and the Development of Anti-viral Resistance

Geoffrey Dusheiko

Anna Maria Geretti

Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy

Patrick Marcellin

Nathalie Boyer

Tarik Asselah

Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin

Ed Gane

Ch. 21- Maintenance Therapy with Oral Anti-viral Agents

Donald M. Jensen

Andrew Aronsohn

Section IV: Liver Transplantation for Chronic HCV

Ch. 22- Natural History of Chronic HCV after Liver Transplantation

Michael Charlton

Bart J. Veldt

Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV

Robert Brown

Elizabeth C. Verna

Ch. 24- Treating HCV Prior to Liver Transplantation

Greg Everson

Alvaro Martinez-Camacho

Brett E. Fortune

Ch. 25- Treating HCV after Liver Transplantation

Sammy Saab

Michael Chang

Hubert Sung