Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.

Preface

Definition of Symbols

Non-Proprietary and Brand Names of Drugs in Text and Illustrations

I. Basic Considerations

• 1. Therapeutic Relevance


• 2. Fundamental Concepts and Terminology



II. Exposure and Response after a Single Dose



• 3. Kinetics Following an Intravenous Bolus Dose


• 4. Membranes and Distribution


• 5. Elimination


• 6. Kinetics Following an Extravascular Dose


• 7. Absorption


• 8. Response Following a Single Dose



III. Therapeutic Regimens



• 9. Therapeutic Window


• 10. Constant-Rate Input


• 11. Multiple Dose Regimens

IV. Individualization

• 12.Variability


• 13.Genetics


• 14. Age, Weight, and Gender


• 15. Disease


• 16. Nonlinearities


• 17. Drug Interactions


• 18. Initiating and Managing Therapy



V. Supplemental Topics



• 19. Distribution Kinetics


• 20. Metabolites and Drug Response


• 21. New! Protein Drugs


• 22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data



Appendices




A. Assessment of AUC




B. Ionization and the pH
Partition Hypothesis




C. Distribution of Drugs
Extensively Bound to Plasma Proteins




D. Plasma-to-Blood Concentration Ratio




E. Well-stirred Model of Hepatic Clearance




F. Absorption Kinetics




G. Wagner-Nelson Method




H. Mean Residence Time




I. Amount of Drug in Body on Accumulation to Plateau




J. Answers to Study Problems