Main description:

Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.

Contents:

1. Epidemiology and Risk Factors for Metastatic Colorectal Disease
2. Molecular Pathogenesis, Tumor Microenvironment and Future Therapeutic Targets: Colorectal Liver Metastasis
3. Pre-operative Imaging, Response Evaluation, and Surgical Planning - CT, PET, Radiomics, FLR Measurement
4. Use of Molecular Markers and Other Personalized factors in Treatment Decisions (KRAS, sidedness etc.)
5. Role of Neoadjuvant Therapy in Treatment of Patients with Colorectal Liver Metastasis
6. Management of the Disappeared Colorectal Liver Metastasis
7. Approach to Small Liver Remnant - Strategies to Increase Resectability
8. Two-Stage versus ALPPS for Large Intrahepatic Burden of Colorectal Liver Metastasis
9. Synchronous Colorectal Liver Metastasis - Simultaneous vs. Staged Approach
10. Minimally Invasive Approaches to Metastatic Colorectal Cancer
11. Hepatic Resection of Colorectal Liver Metastasis in the Presence of Extrahepatic Disease
12. Locoregional Approaches to Colorectal Liver Metastasis - Ablation
13. Locoregional Approaches to Colorectal Liver Metastasis - Intra-arterial
14. Locoregional Approaches to Colorectal Liver Metastasis - Radiation Options
15. Adjuvant Therapy following Resection of Colorectal Liver Metastasis
16. Long-term Prognosis and Surveillance of Patients with Resected Colorectal Liver Metastasis
17. Management of Secondary Recurrence of Intra-hepatic Colorectal Liver Metastasis following Initial Hepatic Resection
18. Immunotherapy and Targeted Therapies for Colorectal Liver Metastasis
19. Colorectal Liver Metastasis: Survivorship