Main description:

Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ss-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.

Contents:

Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold.- Anabolic Response to Cell Swelling in the Liver.- Intercellular Communication and Insulin Secretion.- Expression of the Insulin Gene and Its Regulation.- Implications of the Glucokinase Glucose Sensor Paradigm for Pancreatic ?-Cell Function.- How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in the ?-Cell.- The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction.- Cell Biology of Insulin Action on Glucose Transport: Looking Back.- Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus.- On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition.- Selected References from the Bibliography of Albert E. Renold, M.D.