Main description:

This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

Contents:

Introduction: David Tomlinson (editor of first edition) "Back in my day...."

Fit the First: Clinical Context

Calcutt and Fernyhough: "An introduction to the history and controversies of clinical trials in diabetic neuropathy"

Pop-Busui: "Neuropathy in the DCCT/EDIC - what was done then and what we would do better now"

Bril: "The perfect clinical trial"

Fit the Second: New Models of Diabetic Neuropathy

Calcutt and Fernyhough: "An Introduction to the history and controversies of animal models of diabetic neuropathy"

Gardiner and Freeman: "Can diabetic neuropathy be modeled in vitro?"

Yorek: "Alternatives to the streptozotocin-diabetic rodent"

Fit the Third: Mechanisms and Therapies

Fernyhough and Calcutt: "An introduction to the history and controversies of the pathogenesis of diabetic neuropathy"

Yagihashi: "Glucotoxic mechanisms and related therapeutic approaches"

Zochodne: "Sensory neurodegeneration in diabetes: beyond glucotoxicity "

Dobrowsky: "Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones "

Todorovic: "Painful diabetic neuropathy: Prevention or suppression?"

Fit the Fourth: Translating Science into Medicine

Fernyhough and Calcutt: "New Directions in Diabetic Neuropathy: Evolution or Extinction?"

Vinik, Casellini and Nevoret: "Alternative Quantitative Tools in the assessment of diabetic peripheral and autonomic neuropathy"

Malik: "Wherefore art thou, O Treatment for Diabetic Neuropathy?"