Main description:

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Contents:

Membrane Transporters in Drug Development
The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
Animal Models of Idiosyncratic Drug Reactions
Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
Human Pluripotent Stem Cells for Modelling Toxicity
Disposition of Biologics