Main description:

Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

Contents:

Part I. Cytokines: Induction and Regulation

Transcriptional Regulation of Cytokine Gene Expression in The Subsets
Jyothi Rengarajan and Laurie H. Glimcher

Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells
M. Frances Shannon and Adele F. Holloway

Variant Ligands, Altered T Cell Receptor Signaling, Hierarchial Response Thresholds, and CD4+ Effector Responses
Yasushi Itoh and Ronald N. Germain

The Role of Costimulation in T Cell Differentiation
Janet E. Buhlmann and Arlene H. Sharpe

CD1d-Restricted NK T Cells and Autoimmunity
Mark Exley and S. Brian Wilson

Role of T Cell Death and Cytokines in Autoimmunity
Luk Van Parijs and Abul K. Abbas

Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease
Richard M. Ransohoff and William J. Karpus

Part II. Cytokines: Role in Specific Autoimmune Diseases

Cytokines and Resistance to Organ Specific Autoimmune Disease
Benjamin M. Segal and Ethan M. Shevach

The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis
Rachel R. Caspi

Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis
Estelle Bettelli and Lindsay B. Nicholson

Role of Cytokines in Multiple Sclerosis and Mucosal Tolerance
Howard L. Weiner

Cytokines and Human Type 1 Diabetes
Sally C. Kent, Vissia Viglietta, and David A. Hafler

Cytokines in Human Rheumatoid Arthritis and Murine Models
Marie Wahren-Herlenius, Helena Erlandsson Harris, Per Larsson, and Lars Klareskog

Systemic Lupus Erythematosus
Amy E. Wandstrat and Edward K. Wakeland

Myasthenia Gravis
Premkumar Christadoss and Elzbieta Goluszko

Part III. Cytokines and Autoimmunity: A Synthesis

Cytokines in Autoimmune Disease
Vijay K. Kuchroo and Lindsay B. Nicholson