Main description:

The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.

Contents:

Actin.- Microtubules.- The Kinesin Superfamily.- Myosins.- The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes.- Thin Filament Disease of Stricted Muscle.- Filamin and disease.- LIMK and Cancer Metastasis.- Actin Mutations and Deafness.- Therapeutic Targeting of the Actin Cytoskeleton.- Microtubules as a Target in Cancer Therapy.- Microtubules and drug resistance.- Posttranslational Modifications of Tubulin.- Stathmin and Cancer.- The Biology and Pathobiology of Tau Protein.- Tubulin-Related Malformations of Cortical Development.- Spectrins in Human Diseases.- Laminopathies.- Desmin and Heart Disease.- Neurodegenerative Diseases and Intermediate Filaments.