Main description:

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Contents:

Contents1 Basic rules of T cell migration Jens V. Stein, Federica Moalli and Markus Ackerknecht2 Regulation of anti-tumor T cell migration and function: contribution of real-time imaging Pierre-Louis Loyher, Christophe Combadiere and Alexandre Boissonnas3 Vascular normalization, T cell trafficking and anti-tumor immunity Kellsye L. Fabian and Walter J. Storkus4 Disruption of anti-tumor T cell responses by cancer-associated fibroblasts Arnaud Pommier and Douglas T. Fearon5 Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic Bertrand Dubois, Helene Kaplon, Coline Couillault, Christophe Caux, and Marie-Caroline Dieu-Nosjean6 Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy Joseph M. Cantor7 Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors. Stefano Garetto, Claudia Sardi, Diego Morone and Marinos Kallikourdis8 Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors Yuhui Chen, Gianpietro Dotti and Barbara Savoldo.