Main description:

Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts discuss the bioequivalence of dermatological and transdermal dosage forms. They explore the biochemistry and treatment of skin diseases, the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation.

Contents:

The structure and function of the skin; common skin disorders and their topical treatment; basic mathematical principles in skin permeation; skin transport; methods for studying percutaneous absorption; formulation strategies for modulating skinpermeation; formulation and development of dermatological dosage forms; bioequivalence of dermal and transdermal formulations; scale-up of dermatological dosage forms; a case for multivariate optimization and product homogeneity; transdermal drug deliverysystems; safety considerations for dermal and transdermal products; transdermal delivery and cutaneous reactions.