Main description:

T cells belong to a group of white blood cells called lymphocytes and play a large role in the immune response. An increased understanding of T cell immunity will provide new insights into the etiology of human autoimmune disease such as diabetes.

This volume reviews the latest developments and discusses the evolution of T cell immunity, thymic requirements, and how to prevent T cell-dependent autoimmunity.

Contents:

Development of T cell immunity

The development of T cell immunity - Adrian Liston
The evolution of T cell immunity

Genome duplication and T cell immunity - Masanori Kasahara

Questions arising from "Genome duplication and T cell immunity" - Claude Perreault
Response to questions - Masanori Kasahara

The origin and role of MHC class I-associated self peptides - Claude Perreault

Questions arising from "The origin and role of MHC class I-associated self peptides" - Masanori Kasahara
Response to questions - Claude Perreault

Thymic requirements for T cell immunity

Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation - Nancy Manley and Brian Condie
Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia - Cedric S Tremblay, Thu Hoang and Trang Hoang
T cell immunity in the periphery

Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses - Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson

Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" - Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes

Cellular and Molecular Requirements in Lymph Node and Peyer's Patch Development - Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
T follicular helper cells during Immunity and Tolerance - Michelle A. Linterman and Carola G. Vinuesa
Preventing T cell-dependent autoimmunity

Thymic selection and lineage commitment of CD4+Foxp3+ regulatory T cells - Paola Romagnoli and Joost P.M. van Meerwijk
Molecular Mechanisms of Regulatory T cell Development and Suppressive Function - Jeong M. Kim

Is Foxp3 the master regulator of regulatory T cells? - Adrian Liston