Main description:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.

This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

Contents:

1. The multitude of therapeutic targets in neurodegenerative proteinopathies 2. Synuclein misfolding as a therapeutic target 3. Neuroinflammation as a therapeutic target in neurodegenerative diseases 4A. Stem cells in neurodegeneration: mind the gap 4B. The potential of stem cells in tackling neurodegenerative diseases 5. Preclinical models of Alzheimer's disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy 6. Parkinson's disease 7. Lewy body dementia 8. Frontotemporal dementia 9. From huntingtin gene to Huntington's disease-altering strategies 10. Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies