Completely revised and updated, and now in full color throughout, the Fourth Edition of this definitive reference is a must for all clinicians who treat breast diseases. Leading experts summarize the current knowledge of breast diseases, including their clinical features, management, underlying biologies, and epidemiologies. In addition to complete coverage of malignant breast diseases, benign diseases are discussed in relation to subsequent breast cancer development. The book reviews all major clinical trials and summarizes the information they provide on early detection and management of breast cancer. Close attention is also given to the increasing importance of molecular biology and genetics in this field. This edition features more than thirty new contributors, fourteen new or completely rewritten chapters, and more clinically oriented chapters.

A companion Website will offer the fully searchable text and an image bank.

Also included with this edition is the Anatomical Chart Company's Breast Anatomy and Disorders Pocket Guide. This durable, portable folding pocket guide provides a visual and textual overview of breast anatomy, disorders, and breast self-examination. With a write-on, wipe-off laminated surface, this guide is perfect for the on-the-go practitioner to show patients, caregivers, and families.

Preface

Preface to the First Edition

Contributors

Section I Breast Anatomy and Development

• Chapter 1 Breast Anatomy and Development
• Chapter 2 Molecular Mechanisms Regulating Breast Development
• Chapter 3 Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives

Section II Diagnosis and Management of Benign Breast Diseases

• Chapter 4 Physical Examination of the Breast
• Chapter 5 Management of the Palpable Breast Mass
• Chapter 6 Management of Disorders of the Ductal System and Infections

Section III Breast Imaging and Image-Guided Biopsy Techniques

• Chapter 11 Screening for Breast Cancer
• Chapter 12 Imaging Analysis: Mammography
• Chapter 13 Breast Ultrasound

Section IV Epidemiology and Assessing and Managing Risk

• Chapter 18 Inherited Genetic Factors and Breast Cancer
• Chapter 19 Genetic Testing and Management of Patients with Hereditary Breast Cancer
• Chapter 20 Nongenetic Factors in the Causation of Breast Cancer

Section V In Situ Carcinoma

• Chapter 23 Pathology and Biological Features of Premalignant Breast Disease
• Chapter 24 Lobular Carcinoma In Situ: Biology and Pathology
• Chapter 25 Lobular Carcinoma In Situ: Clinical Management

Section VI Pathology and Biological Markers of Invasive Breast Cancer

• Chapter 27 Breast Cancer Genomics
• Chapter 28 Pathology of Invasive Breast Cancer
• Chapter 29 Clinical Aspects of Estrogen and Progesterone Receptors

Section VII Management of Primary Invasive Breast Cancer

• Chapter 34 Evaluation of Patients for Metastasis Prior to Primary Therapy
• Chapter 35 Staging of Breast Cancer
• Chapter 36 Mastectomy

Section VIII Preoperative Systemic Therapy

• Chapter 58 Preoperative Therapy for Operable Breast Cancer
• Chapter 59 Preoperative Endocrine Therapy for Operable Breast Cancer
• Chapter 60 Local-Regional Therapy Considerations in Patients Receiving Preoperative Chemotherapy

Section IX Special Therapeutic Problems

• Chapter 64 Male Breast Cancer
• Chapter 65 Phyllodes Tumors
• Chapter 66 Paget's Disease

Section X Evaluation after Primary Therapy and Management of Recurrent Breast Cancer

• Chapter 70 Surveillance of Patients Following Primary Therapy
• Chapter 71 Surgery for the Primary in Patients with Distant Metastases
• Chapter 72 Local-Regional Recurrence after Breast-Conservation Treatment or Mastectomy

Section XI New Breast Cancer Therapeutic Approaches

• Chapter 78 Angiogenesis Inhibition in Breast Cancer
• Chapter 79 Tyrosine Kinase Inhibitors
• Chapter 80 Newer Targeted Therapy in Breast Cancer

Section XII Site-Specific Therapy of Metastatic Breast Cancer

• Chapter 81 Brain Metastases
• Chapter 82 Epidural Metastases
• Chapter 83 Leptomeningeal Metastasis

Section XIII Breast Cancer in Special Populations

• Chapter 91 Breast Cancer in Older Women
• Chapter 92 Breast Cancer in Younger Women
• Chapter 93 Breast Cancer in Minority Women

Section XIV Issues in Breast Cancer Survivorship

• Chapter 94 Nursing Care in Patient Management and Quality of Life
• Chapter 95 Psychosocial Adaptation During and After Breast Cancer
• Chapter 96 Reproductive Issues in Breast Cancer Survivors

Section XV Other Considerations

• Chapter 97 Medical Legal Aspects of Breast Cancer Evaluation
• Chapter 98 Cost and Cost-Effectiveness Considerations

Index