Main description:

This book overviews in vivo imaging techniques for both the development of drug delivery systems and controlled release dosages. Written by experts in their respective fields, the book discusses applications of quantitative imaging techniques in drug delivery. It helps readers understand the contemporary use of imaging in preclinical evaluation of drug delivery systems and to recognize challenges and potential pitfalls involved in utilizing imaging in developing new drug delivery systems. The chapters provide useful methods, practices, and guidance for pharmaceutical scientists encountering challenges in designing and evaluating drug delivery systems.

Contents:

Preface ix contributors xi 1 Introduction to Molecular Imaging 1 Vikas Kundra 2 PET/SPECT: Instrumentation and Imaging Techniques 12 Yuan-Chuan Tai 3 Photoacoustic Tomography and Its Applications in Drug Delivery and Photothermal Therapy 45 Liang Song and Lihong V. Wang 4 Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Subcellular Drug Delivery 70 Tatyana Chernenko, Lara Milane, Christian Matthaus, Max Diem, and Mansoor Amiji 5 A natomical and Functional MRI91 Edward F. Jackson 6 Quantitative Imaging in Drug Delivery 125 Kooresh I. Shoghi 7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight Drugs 147 Stephen M. Moerlein and Zhude Tu 8 Imaging Peptides, Proteins, and Antibody Delivery 192 Frederik L. Giesel and Clemens Kratochwil 9 In Vivo Imaging and Delivery of siRNA199 Zdravka Medarova and Anna Moore 10 Imaging Cell Therapy 223 Yajie Liang and Jeff W. M. Bulte 11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics 252 William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins 12 Polymeric Micelles as Imaging Agents and Drug Delivery Systems 268 Jun Zhao and Chun Li 13 Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic 296 G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and S. A. Wickline 14 Cancer Theranostics with Hollow Gold Nanospheres 308 Wei Lu and Chun Li 15 Imaging Pulmonary Drug Delivery 333 Stephen P. Newman 16 In Vivo Imaging for Validation of Oral Dose Performance 367 Fiona J. McInnes and Howard N. E. Stevens 17 Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery 389 Rajesh K. Uthamanthil and Mei Tian 18 Imaging Transcatheter Delivery to Liver Tumors 412 Adil Al-Nahhas, Meeran Naji, and Imene Zerizer 19 Direct Visualization of Therapeutic Radionuclide Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma 426 Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee 20 Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies 432 Chi-Ming Lee, Katarina Varnas, and Lars Farde Index 449