Main description:

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

key interplay between transporters and enzymes in drug metabolism and drug interactions
the integral role of pharmacogenetics in metabolism-based drug-drug interactions
in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)
in silico approaches enabling structure-activity and structure-function studies
high-throughput screening and GLP methods for evaluating drug interactions in vitro
the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

Contents:

Introducing Pharmacokinetics and Pharmacodynamic Concepts. In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes. Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions. UDP-Glucuronosyltransferases. Drug-Drug Interactions Involving the Membrane Transport Process. In Vitro Models for Studying Induction of Cytochrome P450 Enzymes. In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450. The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development. Cytochrome P450 Protein Modeling and Ligand Docking. The Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions. Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations. Transporter-mediated Drug Interactions: Molecular Mechanisms and Clinical Implications. Metabolism & Transport Drug Interaction Database: a web-based research and analysis tool. In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans. Drug-Drug Interactions: Clinical Perspective. An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective. Drug-Drug Interactions: Toxicological Perspectives. Drug-Drug Interactions: Marketing Perspectives.