Main description:

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Contents:

Pharmacokinetics.- Drug Metabolizing Enzymes.- Oral Absorption.- Transporters.- Metabolism-Based Drug Interactions.- Biotransformation and Bioactivation.- Prediction of Human Pharmacokinetics.- Advances in Bioanalysis as it Relates to ADME.- ADME Properties and Their Dependence on Physicochemical Properties.- In Silico ADME Tools.- Approved Drugs.- Chemical Nomenclature.