Main description:

Leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific (proposed) syndrome of liability (schizotaxia)-and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia.

Contents:

Part I. The Etiology and Genetics of Schizophrenia

The Genetic Basis of Schizophrenia
Stephen V. Faraone, Stephen J. Glatt, and Levi Taylor

Early Environmental Determinants of Schizophrenia
Jason Schiffman, John Carter, Ricardo A. Machon, and Sarnoff Mednick

Obstetric Risk Factors for Schizophrenia and Their Relationship to Genetic Predisposition: Following Ariadne's Double-Stranded Thread Through Early Development
Stefano Marenco and Daniel R. Weinberger

Part II. The Vulnerability to Schizophrenia

The Nature of the Prodrome in Schizophrenia
Jaak Rakfeldt and Thomas H. McGlashan

The Nature of Schizotaxia
Stephen V. Faraone, Ming T. Tsuang, and Sarah I. Tarbox

A Neuropsychological Perspective on Vulnerability to Schizophrenia: Lessons From High-Risk Studies
Allan F. Mirsky and Connie C. Duncan

Neurocognitive Deficits in the Biological Relatives of Individuals With Schizophrenia
William S. Kremen and Anne L. Hoff

The Nature and Origin of Socioemotional Deficits in Schizophrenia
Elaine Walker and Karen M. Hochman

Neuroimaging Studies of Nonpsychotic First-Degree Relatives of People With Schizophrenia: Toward a Neurobiology of Vulnerability to Schizophrenia
Larry J. Seidman, Heidi E. Wencel, Colm McDonald, Robin M. Murray, and Ming T. Tsuang

Neurophysiological Endophenotypes in Early Detection of Schizophrenia
Marina Myles-Worsley

Is the Development of Schizophrenia Predictable?
Paola Dazzan, Eugenia Kravariti, Paul Fearon, and Robin M. Murray

Part III. Early Intervention and Prevention of Schizophrenia

Prevention of Schizophrenia and Psychotic Behavior: Definitions and Methodological Issues
C. Hendricks Brown and Stephen V. Faraone

The Treatment of Schizotaxia
Ming T. Tsuang, Sarah I. Tarbox, Levi Taylor, and William S.Stone

Treatment of the Schizophrenia Prodrome
Barbara Cornblatt, Todd Lencz, Christopher Smith, and Andrea Auther

The Role of Genetic Counseling
Debby W. Tsuang, Stephen V. Faraone, and Ming T. Tsuang

Part IV. Challenges for the Near Future

The Biology of Schizotaxia
William S. Stone, Stephen J. Glatt, and Stephen V. Faraone

Molecular Medicine and the Prospects for Prevention and Early Intervention in Schizophrenia
William T. Carpenter, Jr. and James I. Koenig

Index