Main description:

The book offers comprehensive coverage of the many essential topics in the subject including:

Environmental factors and DNA damage

Molecular mechanisms associated to DNA damage by various environmental ( Physical, Chemical and Biological) factors

Synergistic effects of environmental factors

Phytochemicals acting both as DNA protectants and genotoxicants

Experimental models for study of genotoxic potential of environmental factors and protection by phytochemicals

Contents:

1 Introduction to the environmental factors and DNA damage 1

2 Molecular mechanisms of physical environmental factors as DNA-damage agents with special reference to (A) Radiations and (B) Temperature 13

3 Effects of chemical environmental factors (both natural and anthropogenic) on DNA and their modes of action. A. Organic factors (pesticides, dyes) B. Inorganic Factors (Heavy metals) 25

4 Biological factors causing DNA damage. A. Plant-based molecules. B. Animal-based molecules

5 Synergistic effects of environmental factors on DNA damage. A. Introduction to Synergism B. Synergistic effects C. Mechanism of actions

6 Introduction to phytochemicals and their actions on DNA. A. DNA-damaging action. B. DNA-protective function

7 Phytochemicals as DNA protectants and genotoxicants A. Phytochemicals as genotoxicants. B. Plant extract as DNA protectants. C. Isolated compounds as DNA protectants

8 Role of phytochemicals in protection of DNA from damage by different environmental factors. A. Physical factors (Thermal and radiation). B. Chemical factors (Organic and inorganic). C. Biological factors (Plants and animals)

9 DNA protective and genotoxic potential of environmental factors: Experimental models for the study

10 DNA damage: Overview, conclusion, and future perspective