Main description:

This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly - chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

Contents:

Essentials of Apoptosis (2nd edition)

Table of Contents

Preface (2nd edition)
Preface (1st edition)
Contributors

Part I. Molecules and Pathways of Apoptosis

Chapter 1. Caspases: Activation, Regulation and Function
Stefan J. Riedl and Fiona L. Scott

Chapter 2. Bcl-2 Family Proteins
Wenxing Ding and Xiao-Ming Yin

Chapter 3. The Mammalian IAPs: Multi-faceted Inhibitors of Apoptosis
Eric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney and Robert G. Korneluk

Chapter 4. Structure Biology of Programmed Cell Death
Yigong Shi

Chapter 5. The Death Receptor Pathway
Maria Eugenia Guicciardi and Gregory J. Gores

Chapter 6. The Mitochondrial Pathway: Focus on Shape Changes
Silvia Campello and Luca Scorrano

Chapter 7. The Endoplasm Reticulum Pathway
Michael W. Harr and Clark W. Distelhorst

Chapter 8. Reactive Oxygen Species in Cell Fate Decisions
Han-Ming Shen and Shazib Pervaiz

Chapter 9. The Integration of Metabolism and Cell Death
Jonathan L. Coloff, Yuxing Zhao and Jeffrey C. Rathmell

Chapter 10. Transcriptional Regulation of Apoptosis
Crissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang and Jian Yu

Chapter 11. Clearance of Apoptotic cells --Mechanisms and Consequences
Carylin J. Marek and Lars-Peter Erwig

Chapter 12. Systems Biology Approach to the Study of Apoptosis
Heinrich Huber, Eric Bullinger and Markus Rehm

Part II: Apoptosis in Model Organisms

Chapter 13. Programmed Cell Death in Plants: Apoptotic but not Quite
Naohide Watanabe and Eric Lam

Chapter 14. Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae
Didac Carmona-Gutierrez and Frank Madeo

Chapter 15. Programmed Cell Death in C. elegans.
Monica Darland-Ransom, Yi-Chun Wu and Ding Xue

Chapter 16. Cell Death in Drosophila.
Dianne C. Purves, Jessica P. Monserrate and Carrie Baker Brachmann

Part III. Apoptosis in Mammalian Physiology and Pathogenesis

Chapter 17. Cell Death: Defining and Misshaping Mammalian Embryos
Zahra Zakeri and Richard Lockshin

Chapter 18. Matters of Life and Death in the Immune System
Christopher Dillon and Douglas R. Green

Chapter 19.Cell Death in the Hematopoietic System
Emma C. Josefsson and Benjamin T. Kile

Chapter 20 Cell Death in Acute Neuronal Injury
R. Anne Stetler, Armando P. Signore and Jun Chen

Chapter 21. Apoptosis in Neurodegenerative Diseases
Qiuli Liang and Jianhua Zhang

Chapter 22. Apoptosis in Cardiovascular Pathogenesis
Hamid el Azzouzi; Meriem Bourajjaj; Paula A. da Costa Martins and Leon J. De Windt

Chapter 23. Apoptosis in Lung Injury and Disease
Stefan W. Ryter, Hong Pyo Kim, and Augustine M. K. Choi

Chapter 24. Apoptosis in the Liver Injury and Liver Diseases
Yosuke Osawa, Ekihiro Seki, and David A Brenner

Chapter 25. Apoptosis in Kidney Injur