Main description:

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more.

Contents:

The computational modeling of allosteric modulation of metabotropic glutamate receptors
Laura Perez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern

Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators
Kirstie A. Bennett, John A. Christopher and Benjamin G. Tehan

The function and allosteric control of the human sweet taste receptor
Guy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant

The different aspects of the GABAB receptor allosteric modulation
Julie Kniazeff

RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors
Augen A. Pioszak and Debbie L. Hay

Strategies and considerations of G-protein-coupled receptor photopharmacology
Alice E. Berizzi and Cyril Goudet

Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacology
Francis S. Willard, Joseph D. Ho and Kyle W. Sloop

Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations
Kari A. Johnson and David M. Lovinger

Allosteric modulation of muscarinic receptors in alcohol and substance use disorders
Leigh C. Walker and Andrew J. Lawrence

M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?

Miriam Scarpa, Sarah Hesse and Sophie J. Bradley