Main description:

This book presents the basic principles and new and emergent clinical applications of BOLD fMRI. It describes the physical principles of BOLD fMRI imaging and reviews scanning methodologies, data analysis, challenges and limitations of BOLD fMRI, neurovascular uncoupling, and functional connectivity. The book also explores current and future clinical applications of BOLD fMRI in the fields of language, memory, fMRI WADA, visual pathway, brain mapping of eloquent cortex, pediatrics, auditory pathways, epilepsy, psychiatric disorders, neurodegenerative disorders, pharmacological applications, and cognitive neuroscience. It concludes with a discussion of BOLD fMRI paradigms that can be used for clinical and cognitive experiments. Derived from Faro, Mohamed, Law, and Ulmer's Functional Neuroradiology: Principles and Applications, this book is a valuable resource for neurologists, cognitive neuroscientists, and neuroradiologists.

Contents:

Part I BOLD Functional MRI: Physical Principles

1 Principles of BOLD Functional MRI

Seong-Gi Kim and Peter A. Bandettini

2 fMRI Scanning Methods

Alexander B. Pine and Feroze B. Mohamed

3 Experimental Design and Data Analysis for fMRI

Geoffrey K. Aguirre

4 Challenges in fMRI and Its Limitations

R. Todd Constable

5 Neurovascular Uncoupling in Functional MR Imaging

Jorn Fierstra and David John Mikulis

6 Functional Connectivity MR Imaging

Michelle Hampson, Xilin Shen, and R. Todd Constable

7 Clinical Challenges of Functional MRI

Nader Pouratian and Susan Y. Bookheimer

Part II Neuroanatomical Atlas

8 Neuroanatomical Atlas of Key Presurgical and Cognitive Eloquent Cortex Regions

Feroze B. Mohamed, Michael Yannes, Muhammed Malik, and Scott H. Faro

Part III BOLD Functional MRI: Clinical Applications

9 fMRI of Language Systems: Methods and Applications

Jeffrey R. Binder

10 Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer's Disease

Shannon L. Risacher, Heather A. Wishart, and Andrew J. Saykin

11 fMRI Wada Test: Prospects for Presurgical Mapping of Language and Memory

Brenna C. McDonald, Jacob Kean, and Andrew J. Saykin

12 fMRI of Human Visual Pathways

Edgar A. DeYoe, John L. Ulmer, Wade Mueller, Lotfi Hacein-Bey, Viktor Szeder, Mary Jo Maciejewski, Karen Medler, Danielle Reitsma, and Jedediah Mathis

13 Brain Mapping for Neurosurgery and Cognitive Neuroscience

Joy Hirsch

14 Pediatric Applications of fMRI

Nolan R. Altman and Byron Bernal

15 fMRI of the Central Auditory System

Deborah A. Hall

16 fMRI of Epilepsy

Karsten Krakow

17 Applications of fMRI to Psychiatry

Melissa Lopez-Larson and Deborah A. Yurgelun-Todd

18 Applications of fMRI to Neurodegenerative Disease

Shamseldeen Y. Mahmoud, Stephen E. Jones, and Michael D. Phillips

19 Applications of MRI to Psychopharmacology

Dan J. Stein, Yihong Yang, and Betty Jo Salmeron

20 Functional MRI: Cognitive Neuroscience Applications

Mark D'Esposito, Andrew S. Kayser, and Anthony J.W. Chen

Part IV BOLD fMRI Paradigms

21 BOLD fMRI Paradigms

Feroze B. Mohamed and Scott H. Faro